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| Name | Class |
|---|---|
| Jilin University | OTHER |
| Xi'an Jiaotong University | OTHER |
| Second People's Hospital of Yunnan Province | OTHER |
| Wuhan General Hospital of Guangzhou Military Command |
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Based on the corneal morphometry instrumentation Oculus Pentacam, which is commonly used before and after clinical refractive surgery, we will collect the corneal morphological and biologic parameters of the population under refractive surgery screening in refractive surgery centers around the country, and construct corneal morphology database in different living areas of Chinese people. Based on this, compared with the suspected keratoconus and keratoconus population, the screening criteria and reference standards accord with the characteristics of keratoconus of Chinese ethnic will be achieved.
The safety of refractive surgery has always been the focus of attention, keratoconus screening is the most important part for the preoperative examination of refractive surgery. Favorable tools and appropriate indicators are the premise of fast and accurate screening, and the corneal morphology from various regions of China have various characteristics, the use of uniform standards developed by foreign screening will always induce a lot of problems, for example, the differences of cornea morphological features between European and American ethnic and Chinese race, as well as the corneal morphometric indicators between various regions of China, will cause varying degrees of false-positive or false-negative screening results. Based on this, in order to further improve the safety of refractive surgery effectively and to obtain the effective and accurate screening of suspected keratoconus population, this study will be conducted to collect the corneal morphological characteristics database of Chinese people from all over the country, and to develop a database of Chinese ethnographic characteristics for screening keratoconus indicators and reference valuable to guide clinical screening and surgical design.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Chinese population | Chinese population of different nation from several provinces. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Scheimpflug tomography system (Pentacam) measurement | Device | The Scheimpflug tomography system (Pentacam,Oculus GmbH, Wetzlar, Germany) is a rotating Scheimpflug camera that measures 138,000 true elevation points to compute corneal topography. Patients were asked to blink twice and then look at the fixation device. Image acquisition was a 2-second scan of 50 rotational Scheimpflug images through the corneal sighting point, the point where the ray of light from the fovea to the fixation device crossed the cornea. All measurements were performed just after a blink to minimize the effect of tear film alteration on the data. Acceptable maps had at least 10.0 mm of corneal coverage with no extrapolated data in the central 9.0 mm zone. |
| Measure | Description | Time Frame |
|---|---|---|
| corneal thickness | preoperative |
| Measure | Description | Time Frame |
|---|---|---|
| corneal curvature measured by the Pentacam system | preoperative | |
| coma aberration measured by the Pentacam system | preoperative | |
| aspherical index measured by the Pentacam system |
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Inclusion Criteria:
Exclusion Criteria:
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Chinese population of different nation from several provinces,including Jilin, Xi'an, Yunnan, Wuhan,etc.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yan Wang, director | Contact | +86-02227305083 | wangyan7143@vip.sina.com | |
| Lin Zhang | Contact | +86-02227305083 | zhanglin_2015@126.com |
| Name | Affiliation | Role |
|---|---|---|
| Yan Wang, director | Tianjin Eye Hospital | Study Director |
| Xiaoyu li | Second People's Hospital of Yunnan Province | Principal Investigator |
| Yan Zhang |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tianjin Eye Hospital | Recruiting | Tianjin | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27515569 | Background | Silverman RH, Urs R, RoyChoudhury A, Archer TJ, Gobbe M, Reinstein DZ. Combined tomography and epithelial thickness mapping for diagnosis of keratoconus. Eur J Ophthalmol. 2017 Mar 10;27(2):129-134. doi: 10.5301/ejo.5000850. Epub 2016 Aug 8. | |
| 27805316 | Background | Chan TCY, Biswas S, Yu M, Jhanji V. Comparison of corneal measurements in keratoconus using swept-source optical coherence tomography and combined Placido-Scheimpflug imaging. Acta Ophthalmol. 2017 Sep;95(6):e486-e494. doi: 10.1111/aos.13298. Epub 2016 Nov 2. |
| Label | URL |
|---|---|
| Combined tomography and epithelial thickness mapping for diagnosis of keratoconus. | View source |
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| ID | Term |
|---|---|
| D003316 | Corneal Diseases |
| ID | Term |
|---|---|
| D005128 | Eye Diseases |
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| ID | Term |
|---|---|
| D014894 | Weights and Measures |
| ID | Term |
|---|---|
| D008919 | Investigative Techniques |
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| OTHER |
| Xinjiang Medical University | OTHER |
| Gansu Provincial Hospital | OTHER |
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|
| preoperative |
| spherical aberration measured by the Pentacam system | preoperative |
| corrected distance visual acuity | preoperative |
| uncorrected distance visual acuity | preoperative |
| refractive diopter | preoperative |
| corneal volume measured by the Pentacam system | preoperative |
| kapple angle measured by the Pentacam system | preoperative |
| introcular pressure | preoperative |
| corneal diameter measured by the Pentacam system | preoperative |
| anterior chamber depth measured by the Pentacam system | preoperative |
| anterior chamber angle measured by the Pentacam system | preoperative |
| Jilin University |
| Principal Investigator |
| Jun Yang | Gansu Provincial Hospital | Principal Investigator |
| Jing Li | Xi'an Jiaotong University | Principal Investigator |
| Xianglong Yi | Xinjiang Medical University | Principal Investigator |
| Zhengwei Shen | Wuhan General Hospital of Guangzhou Military Command | Principal Investigator |
| 27626155 | Background | Patrao LF, Canedo AL, Azevedo JL, Correa R, Ambrosio R Jr. Differentiation of mild keratoconus from corneal warpage according to topographic inferior steepening based on corneal tomography data. Arq Bras Oftalmol. 2016 Jul-Aug;79(4):264-7. doi: 10.5935/0004-2749.20160075. |
| 27783185 | Background | Naderan M, Rajabi MT, Zarrinbakhsh P, Farjadnia M. Is keratoconus more severe in pediatric population? Int Ophthalmol. 2017 Oct;37(5):1169-1173. doi: 10.1007/s10792-016-0382-5. Epub 2016 Oct 25. |
| 33620373 | Derived | Ma J, Zhao L, Yang Y, Yun D, Yu-Wai-Man P, Zhu Y, Chen C, Li JO, Li M, Zhang Y, Cui T, Meng X, Zhang L, Zhang J, Song Y, Lei Y, Liu J, Huangfu X, Jiang L, Cai J, Wu H, Shang L, Wen D, Yi X, Zhang Y, Li X, Xiao J, He R, Yang Y, Yang J, Cheng GPM, Bai J, Zhong X, Guo H, Yan P, Wang Y, Lin H. Associations Between Regional Environment and Cornea-Related Morphology of the Eye in Young Adults: A Large-Scale Multicenter Cross-Sectional Study. Invest Ophthalmol Vis Sci. 2021 Feb 1;62(2):35. doi: 10.1167/iovs.62.2.35. |
| Comparison of corneal measurements in keratoconus using swept-source optical coherence tomography and combined Placido-Scheimpflug imaging | View source |
| Differentiation of mild keratoconus from corneal warpage according to topographic inferior steepening based on corneal tomography data | View source |
| Is keratoconus more severe in pediatric population? | View source |