A Study of Metabolic Agents Following Brain Radiation

Pilot Imaging Study for CNS Metabolism

This study is being done to determine if CEST magnetic resonance imaging (MRI) and FDG PET are feasible techniques to detect metabolic differences between tumor and brain in patients with a brain tumor.

Inclusion Criteria:

• Radiographic evidence or histopathologic confirmation of CNS malignancy, with or without prior resection.
• Provide written informed consent for the current study.
• Willing to undergo at least one MRI (and possibly more at PI discretion) with proton and/or phosphorus magnetic resonance spectroscopy analysis.

Exclusion Criteria:

• Vulnerable populations: pregnant or nursing women (Arm B exempt), prisoners, mentally handicapped.
• Cardiac pacemaker or artificial heart valve
• Metal plate, pin, or other metallic implant
• Intrauterine device, such as Copper-7 IUD
• Insulin or other drug pump
• Non-titanium aneurysm clips
• Previous gunshot wound
• Cochlear implant or other hearing device
• Employment history as a metalworker (had metal in eye)
• Permanent (tattoo) eye-liner
• For FDG-PET specifically: Fasting blood sugar level greater than 200mg/dl