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| ID | Type | Description | Link |
|---|---|---|---|
| 2022-A00910-43 | Other Identifier | ID-RCB Number |
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Standard Magnetic Resonance Imaging (MRI) is based on the excitation of hydrogen nuclei that are presents in water molecules, which abundance in human body allows for obtention of superior contrast. However, assessing the presence of other molecules than water in tissues is also of great clinical interest to probe metabolites related to physiological body function and pathological conditions.
Chemical exchange saturation transfer (CEST) allow to overcome some limitations of proton magnetic resonance spectroscopy (1H-MRS) by exploiting chemical properties of the targeted molecule through a continuous process of re-saturation and exchange, and thus detecting it with increased sensitivity, from two orders of magnitude. Moreover, CEST technique is based on imaging sequences and can therefore benefit from well-known fast acquisition strategies, as well as improved spatial resolution.
For this study the investigators propose to include an additional CEST sequence in standard PET/MRI exam in order to obtain a cartography with biochemical informations from tissues in patients with glioma or brain metastases.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with glioma or brain metastases | Other |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Additional CEST sequences during PET/MRI exam | Other | CE-Marked Advanced Technology Software Modules (ATSM) for Magnetic Resonance Imaging from General Electric Healthcare |
|
| Measure | Description | Time Frame |
|---|---|---|
| Obtention, from a set of brain PET-MRI images, of an intratissular pH mapping in patients with glioma or brain metastases | Evaluation at the cerebral level on the acquisition images of residual volume in MRI | through study completion, up to 14 years |
| Obtention, from a set of brain PET-MRI images, of an intratissular pH mapping in patients with glioma or brain metastases | Evaluation at the cerebral level on the acquisition images of tumoral metabolic activity in PET | through study completion, up to 14 years |
| Measure | Description | Time Frame |
|---|---|---|
| Correlate intratissular pH mapping and location of recurrence | through study follow-up, up to 10 years | |
| Correlate average pH of the tumor and histopathology | through study follow-up, up to 10 years |
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Inclusion Criteria:
Patients admitted to the Nuclear Medicine and Molecular Imaging department of ICANS (Institut de cancérologie strasbourg Europe) for a PET/MRI exam dedicated to:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Manon VOEGELIN | Contact | (0)368339523 | 33 | promotion-rc@icans.eu |
| Claire VIT | Contact | (0)368339523 | 33 | promotion-rc@icans.eu |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| France Institut de cancérologie Strasbourg Europe | Recruiting | Strasbourg | France |
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| ID | Term |
|---|---|
| D005910 | Glioma |
| D001932 | Brain Neoplasms |
| ID | Term |
|---|---|
| D018302 | Neoplasms, Neuroepithelial |
| D017599 | Neuroectodermal Tumors |
| D009373 | Neoplasms, Germ Cell and Embryonal |
| D009370 | Neoplasms by Histologic Type |
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| Correlate average pH of the tumor and Disease-Free Survival (DFS) | through study follow-up, up to 10 years |
| Correlate average pH of the tumor and Overall survival (OS) | through study follow-up, up to 10 years |
| D009369 | Neoplasms |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009380 | Neoplasms, Nerve Tissue |
| D016543 | Central Nervous System Neoplasms |
| D009423 | Nervous System Neoplasms |
| D009371 | Neoplasms by Site |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |