This clinical trial aims to learn about the efficacy of MLYAAT-1002® (a proprietary anti-aging complex, MLYAAT is short for "multi-layer anti-ageing technology" ) in female subjects who have newly received the rejuvenation treatment by comparing visual clinical scores, skin attributes measurement and image analysis.

The main expectation it aims to answer are:

• After the 4-week continuous use of the test skin product with MLYAAT-1002®, the skin aging problem is significantly improved compared with it of controlled product.
• After the single use of the test skin product with MLYAAT-1002®, the instant skin irritation after the Fotona4D Pro® treatment ( a nonablative fractional laser treatment for facial skin rejuvenation) is significantly lower compared with it of controlled product.
• After the 4-week continuous use of the test skin product with MLYAAT-1002®, the skin TEWL (transepidermal water loss) is significantly recovered from the Fotona4D Pro® treatment compared with it of controlled product. And the skin TEWL after the 4-week continuous use of test product is improved or not significantly worse than it before the Fotona4D Pro® treatment.
• After the 4-week continuous use of the test skin product with MLYAAT-1002®, no skin irritation symptom is worsen compared to it after the Fotona4D Pro® treatment.

Inclusion Criteria:

• females aged 30-50
• no history of cosmetic allergies
• according to SKIN AGING ATLAS 2(Asian Type), the scores of under-eye wrinkles, pore appearance, forehead wrinkles are all > 2
• non-sensitive skin
• acceptable for split-face use of products for 28 days
• no using history of antibiotic in the past three months
• written informed consent and portrait right consent were obtained from all participants before study entry

Exclusion Criteria:

• subjects with known allergies or sensitivities to the ingredients in any of the study products
• anyone who is pregnant, nursing an infant, or planning a pregnancy during the study
• any symptoms of facial flushing, erythema, papules, desquamation, or edema as evaluated by a physician prior to initial screening or Fotona4D Pro treatment
• unhealed skin lesions
• participated in any other clinical trial within one month
• received facial skin treatments including but not limited to lasers, chemical peels, dermal fillers within one year
• taken/injected anti-allergy medication in the past one month
• other medical reasons that could affect the test results
• participants in other clinical trials at the same time