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This study aims to assess the risk factors and evaluate the long-term outcomes of patients with coronary chronic total occlusion (CTO) treated with percutaneous coronary intervention or medical treatment.
Coronary artery disease (CAD) is still one of the major contributors to global mortality. CTO is a special lesion type of CAD, defined as complete occlusion of at least one major epicardial coronary artery more than 3 months. Compared to non-CTO patients, those with CTO have worse prognosis. The prognosis of CTO patients is related to many factors including the baseline characteristics, modality of treatment and the degree of coronary collateral formation. Figuring out the factors which can indicate the outcomes of CTO is essential to clinical decision making. In this single center, observational study, we collect patient's clinical characteristics and blood samples to investigate potential factors associated with the development of coronary collateral formation and outcomes in patents with stable coronary artery disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with good coronary collaterals | Coronary collateral circulation development was graded according to the Rentrop score, grade 2 (partial filling of the epicardial segment by collateral vessels); grade 3 (complete filling of the epicardial artery by collateral vessels) were defined as good coronary collateral circulation. |
| |
| Patients with poor coronary collaterals | Coronary collateral circulation development was graded according to the Rentrop score, grade 0 (no filling of any collateral vessels) and grade 1 (filling of side branches of the artery to be perfused by collateral vessels without visualization of the epicardial segment) were defined as poor coronary collateral circulation. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Coronary angiography | Procedure |
|
| Measure | Description | Time Frame |
|---|---|---|
| The degree of collateral estimated visually by Rentrop score during coronary angiography | The degree of coronary collateralization supplying the distal area of the total coronary occlusion was visually graded using the Rentrop scoring system as follows: 0=no visible collaterals; 1=poorly opacified collaterals with faint visualization of the distal vessel; 2=partial filling of the collateral vessels; and 3=complete filling of the collateral vessels. Patients were then classified as poor coronary collaterals (Rentrop scores of 0 and 1) or good coronary collaterals (Rentrop scores of 2 and 3), according to the Rentrop score. | Immediate post-angiography |
| Composite event of all-cause mortality, non-fatal myocardial infarction, heart failure and repeat revascularization | up to 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| Event of all-cause mortality | up to 5 years | |
| Event of death from cardiac causes | up to 5 years | |
| Event of heart failure |
| Measure | Description | Time Frame |
|---|---|---|
| The level of serum markers and biochemical indexes which have been reported to closely related to cardiovascular diseases and collateral formation. | up to 5 years |
Inclusion Criteria:
Exclusion Criteria:
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Patients with coronary artery disease and CTO undergone coronary angiography at Ruijin Hospital, Shanghai, China will be consecutively enrolled.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Fenghua Ding, PhD, MD | Contact | 0086 021 64370045 | ruijindfh@126.com |
| Name | Affiliation | Role |
|---|---|---|
| Fenghua Ding, PhD, MD | Ruijin Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ruijin Hospital, Shanghai Jiao Tong University School of Medicine | Recruiting | Shanghai | China |
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| ID | Term |
|---|---|
| D003324 | Coronary Artery Disease |
| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| up to 5 years |
| The change of left ventricular ejection fraction | 1 year |
| Events of repeat revascularization | up to 5 years |
| Event rate of procedural success | Immediate post-PCI |
| Event of procedural outcomes | 1 month post-angiography or PCI |
| D001161 |
| Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |