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As human life expectancy increases, the prevalence of degenerative osteoarthritis of the knee joints is steadily rising, leading to a significant surge in the frequency of total knee arthroplasty (TKA). However, research on sarcopenia in the population that comprises the primary recipients of these orthopedic joint surgeries has been notably lacking. Since the release of the 2019 Consensus update on sarcopenia by the Asian Walking Group for Sarcopenia (AWGS) in 2020, research on sarcopenia has gained momentum in various domains. Yet, as previously mentioned, the field of orthopedics still lags behind in investigating sarcopenia. Therefore, it is believed that establishing the relationship between sarcopenia and surgical outcomes in the elderly, who are the primary targets of orthopedic joint replacement surgery, could offer insights to further enhance the results of joint replacement surgeries.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sarcopenia | Experimental | Patients were categorized into preoperative sarcopenia |
|
| normal | No Intervention | normal groups according to the AWGS 2019 criteria. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Arm I (Sarcopenia) | Procedure | Same as standard treatment |
| |
| Measure | Description | Time Frame |
|---|---|---|
| handgrip strength, gait speed, SPPB, ASM) | Handgrip strengths were measured using a handgrip dynamometer before surgery. low muscle mass AND (low physical performance OR low strength) : sarcopenia low muscle mass AND (low physical performance AND low strength) : severe sarcopenia | 6, 12months after surgery |
| gait speed | Gait speed was measured using a dedicated camera equipped with LiDAR sensors. | 6, 12months after surgery |
| SPPB | The Short Physical Performance Battery was measured using a dedicated device that included a force plate. | 6, 12months after surgery |
| ASM | Appendicular Skeletal Muscle Mass was measured through Bioelectrical Impedance Analysis. | 6, 12months after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Knee Society Score | The original KSS has a "Knee Score" section (7 items) and a "Functional Score" section (3 items). Both sections are scored from 0 to 100 with lower scores being indicative of worse knee conditions and higher scores being indicative of better knee conditions | 3, 6, and 12months after surgery |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Byungwoo Cho | Contact | 82-2-2019-3419 | gsirb@yuhs.ac |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| GangnamSeverance Hospital | Recruiting | Seoul | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32033882 | Background | Chen LK, Woo J, Assantachai P, Auyeung TW, Chou MY, Iijima K, Jang HC, Kang L, Kim M, Kim S, Kojima T, Kuzuya M, Lee JSW, Lee SY, Lee WJ, Lee Y, Liang CK, Lim JY, Lim WS, Peng LN, Sugimoto K, Tanaka T, Won CW, Yamada M, Zhang T, Akishita M, Arai H. Asian Working Group for Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment. J Am Med Dir Assoc. 2020 Mar;21(3):300-307.e2. doi: 10.1016/j.jamda.2019.12.012. Epub 2020 Feb 4. | |
| 33397990 |
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| ID | Term |
|---|---|
| D020370 | Osteoarthritis, Knee |
| ID | Term |
|---|---|
| D010003 | Osteoarthritis |
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
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This study has prospective cohort design. Prior to surgery, a sarcopenia assessment was conducted to categorize patients into sarcopenia and normal groups. Sarcopenia was reassessed at 6 and 12 months post-surgery for comparison with the preoperative state. Additionally, clinical outcomes of patients were evaluated at 3, 6, and 12 months post-surgery for comparison between the normal and sarcopenia groups.
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| Arm II(Normal) |
| Procedure |
Same as standard treatment |
|
| WOMAC |
Higher scores indicate worse pain, stiffness, and functional limitations. The WOMAC measures five items for pain (score range 0-20), two for stiffness (score range 0-8), and 17 for functional limitation (score range 0-68). |
| 3, 6, and 12months after surgery |
| EQ-5D | The EuroQol 5 Dimension (EQ-5D) is a self-report survey that measures quality of life across 5 domains: mobility, self-care, usual activities, pain/discomfort, and anxiety/depression | 3, 6, and 12months after surgery |
| UCLA score | The UCLA Activity Scale (UCLA) is a questionnaire assessing physical activity level from 1 (low) to 10 (high) in patients undergoing hip or knee arthroplasty | 3, 6, and 12months after surgery |
| Background |
| Lopez de la Oliva AR, Campos-Sandoval JA, Gomez-Garcia MC, Cardona C, Martin-Rufian M, Sialana FJ, Castilla L, Bae N, Lobo C, Penalver A, Garcia-Frutos M, Carro D, Enrique V, Paz JC, Mirmira RG, Gutierrez A, Alonso FJ, Segura JA, Mates JM, Lubec G, Marquez J. Author Correction: Nuclear Translocation of Glutaminase GLS2 in Human Cancer Cells Associates with Proliferation Arrest and Differentiation. Sci Rep. 2021 Jan 4;11(1):249. doi: 10.1038/s41598-020-80651-0. No abstract available. |
| 23188719 | Background | Pichonnaz C, Bassin JP, Currat D, Martin E, Jolles BM. Bioimpedance for oedema evaluation after total knee arthroplasty. Physiother Res Int. 2013 Sep;18(3):140-7. doi: 10.1002/pri.1540. Epub 2012 Nov 27. |
| 32472735 | Background | Wagner DR. Case study: Effect of surgical metal implant on single frequency bioelectrical impedance measures of an athlete. Physiol Rep. 2020 Jun;8(11):e14464. doi: 10.14814/phy2.14464. |
| 32629511 | Background | Ardeljan AD, Polisetty TS, Palmer J, Vakharia RM, Roche MW. Comparative Analysis on the Effects of Sarcopenia following Primary Total Knee Arthroplasty: A Retrospective Matched-Control Analysis. J Knee Surg. 2022 Jan;35(2):128-134. doi: 10.1055/s-0040-1713355. Epub 2020 Jul 6. |
| 30337254 | Background | Babu JM, Kalagara S, Durand W, Antoci V, Deren ME, Cohen E. Sarcopenia as a Risk Factor for Prosthetic Infection After Total Hip or Knee Arthroplasty. J Arthroplasty. 2019 Jan;34(1):116-122. doi: 10.1016/j.arth.2018.09.037. Epub 2018 Sep 20. |
| 33786069 | Background | Liao CD, Chen HC, Huang SW, Liou TH. Impact of sarcopenia on rehabilitation outcomes after total knee replacement in older adults with knee osteoarthritis. Ther Adv Musculoskelet Dis. 2021 Mar 12;13:1759720X21998508. doi: 10.1177/1759720X21998508. eCollection 2021. |
| 27316697 | Background | Shin KY, Park KK, Moon SH, Yang IH, Choi HJ, Lee WS. Vitamin D deficiency adversely affects early post-operative functional outcomes after total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc. 2017 Nov;25(11):3424-3430. doi: 10.1007/s00167-016-4209-8. Epub 2016 Jun 17. |
| 41313412 | Derived | Lee WS, Park KK, Kwon HM, Park JY, Kim TH, Cho BW. A prospective, single-center longitudinal study on the operational definition of sarcopenia in patients undergoing total knee arthroplasty. Eur Geriatr Med. 2026 Apr;17(2):877-885. doi: 10.1007/s41999-025-01368-9. Epub 2025 Nov 28. |
| D012216 |
| Rheumatic Diseases |