Efficacy Evaluation of Two Different Fluoride Applications

Evaluation of Effectiveness of a Novel Remineralizing Agent: A Randomized Controlled Clinical Trial

The goal of this clinical trial is to evaluate the remineralizing or preservative effect of two different fluoride-containing products. The main question aims to answer how the mineral content of the active white spot lesions change after the treatment with those two fluoride applications in a split-mouth design by measuring their mineral content via QLF technology.

Each patient will receive both treatments in a split-mouth design. It is comparison between an experimental fluoride application and Fluoride Protector S.

Inclusion Criteria:

• At least two active non-cavitated white spot lesions on buccal surfaces of anterior teeth or premolars (ICDAS code 1 and 2; Nyvad score 1) in two different quadrants.
• Age between 13 and 50 years
• No untreated caries lesions or periodontal disease
• No systematic disease or medication (such as antidepressants, antibiotics etc.) that affects salivary flow rate
• Subjects claimed regular brushing at least twice a day
• Subjects had to agree to keep the scheduled recall appointments for at least 1 year.

Exclusion Criteria:

• Inactive non-cavitated lesions (Nyvad Score 4)
• Lesions with microcavity, cavitation, chipping or discoloration
• Lesions at buccal side of the molars
• Lesions adjacent to restoration
• Developmental white spot lesions such as enamel hypoplasia
• Pregnancy