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| Name | Class |
|---|---|
| Research Grants Council, Hong Kong | OTHER |
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To assess the effects of a dual-task exercise program on cognitive-motor interference during dual-task walking and the associated changes in brain activity.
Stroke is one of the leading causes of chronic disability in Hong Kong and other parts of the world. Mobility dysfunctions are among the most common impairments observed after stroke. Restoration of mobility is also a top priority in rehabilitation goal-setting by stroke patients. In daily life, functional ambulation in the community requires the ability to maintain walking balance while simultaneously engaging in other attention-demanding tasks (i.e., dual-tasking), such as walking when holding a conversation, or crossing the street while attending to traffic signals. There is increasing evidence that performing a cognitive task in conjunction with a mobility task would cause more severe degradation of one or both tasks among stroke patients when compared with age-matched able-bodied individuals. This phenomenon, termed "cognitive-motor interference", should warrant detailed study, since it has an important impact on community-living among people with stroke.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Dual-task training | Experimental | Mobility tasks performed in conjunction with cognitive tasks |
|
| Single-task training | Active Comparator | Separate cognitive and mobility exercises |
|
| Control group | Active Comparator | Upper limb strengthening and flexibility exercises |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dual-task training | Behavioral | This group will receive 30 min of dual-task exercise training and 30 min of stretching exercises in each session. The dual-task component involves walking activities performed in conjunction with cognitive activities. For the stretching exercise component, no cognitive load will be added. |
| Measure | Description | Time Frame |
|---|---|---|
| Dual-task gait speed | Gait speed under dual-task condition will be recorded | Through study completion, an average of 1 year |
| Dual-task cognitive performance | Number of correct responses will be measured during dual-task walking | Through study completion, an average of 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Dual-task gait performance 1 | Gait cadence will be measured during dual-task walking | Through study completion, an average of 1 year |
| Dual-task gait performance 2 | Stride length will be measured during dual-task walking |
| Measure | Description | Time Frame |
|---|---|---|
| Single-task walking speed | 10-meter walking test will be used to assess single-task walking speed in meters per second | Through study completion, an average of 1 year |
| Balance 1 | Mini Balance Evaluation Systems Test will be used to assess postural control, with total points from 0-28. Higher points indicate better performance. |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Marco Yiu Chung PANG, PhD | Contact | 2766-7156 | 2766-7156 | Marco.Pang@polyu.edu.hk |
| Name | Affiliation | Role |
|---|---|---|
| Marco Yiu Chung PANG, PhD | The Hong Kong Polytechnic University | Principal Investigator |
| Xun LI, MSc | The Hong Kong Polytechnic University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Hong Kong Polytechnic University | Recruiting | Hong Kong | 000000 | Hong Kong |
The study data can be provided via contacting the Principal Investigator
From Dec 2025 onwards
By contacting the Principal Investigator (Prof. Marco PANG): Marco.Pang@polyu.edu.hk
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| ID | Term |
|---|---|
| D020521 | Stroke |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D035061 | Control Groups |
| ID | Term |
|---|---|
| D015340 | Epidemiologic Research Design |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D012107 | Research Design |
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After stratification according to gender and walking speed, the participants will be randomly allocated to one of three groups: (1) dual-task training, (2) single-task training, and (3) control intervention, using a 1:1:1 allocation ratio.
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This will be a single-blinded RCT. The assessor will be blinded during assessments. The participants and investigators (trainers) are not possible to be blinded as it is an exercise intervention.
|
| Single-task training | Behavioral | This group will undergo 30 min of single-task mobility training and another 30 min of single-task cognitive activities. The cognitive and mobility exercises will be the same as those in the dual-task group, but they will be performed separately. No extra cognitive load will be imposed during the mobility exercises. No additional motor demand will be imposed during the cognitive exercises, as the participants will be sitting. |
|
| Control group | Behavioral | This group will undergo 30 min of stretching exercises (same as the dual-task group) and another 30 min of upper limb strengthening exercises performed primarily in the sitting or lying position. No cognitive load will be added. |
|
| Through study completion, an average of 1 year |
| Dual-task gait performance 3 | Trunk stability will be measured during dual-task walking | Through study completion, an average of 1 year |
| Oxyhemoglobin concentration changes of the brain | Oxyhemoglobin concentration changes will be measured using functional near infra-red spectroscopy during dual-task walking | Through study completion, an average of 1 year |
| Through study completion, an average of 1 year |
| Balance 2 | Activities-specific Balance Confidence Scale will be used to assess confidence of functional balance performance, with total points from 0-100. Higher points indicate better performance. | Through study completion, an average of 1 year |
| Cognitive performance | Stroop color word test will be used to assess executive function | Through study completion, an average of 1 year |
| Cognitive performance 1 | Digit Span Test will be used to assess working memory | Through study completion, an average of 1 year |
| Cognitive performance 2 | Montreal Cognitive Assessment will be used to assess global cognition, with total points from 0-30. Higher points indicate better performance. | Through study completion, an average of 1 year |
| Fall incidence | Monthly telephone interviews for recording fall incidence | Through study completion, an average of 1 year |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D008722 | Methods |