Preemptive Oral Gabapentin and Tramadol on Postoperative Pain After Knee Arthroscopy

Preemptive Oral Gabapentin Versus Tramadol on Postoperative Pain After Knee Arthroscopy Done Under Spinal Anesthesia: A Prospective Randomized Trial

The aim of this study to evaluate the effect of preemptive oral gabapentin versus tramadol on postoperative pain after knee arthroscopy under spinal anesthesia.

Orthopedic surgeries are frequently associated with moderate-to-severe postoperative pain that can decrease mobility in the immediate postoperative period, interfere with postoperative rehabilitation, and delay hospital discharge. Pain may also become chronic.

Spinal anesthesia is the most popular anesthesia technique worldwide in orthopedic lower limb surgeries. However, its relatively short duration of action may limit the excellent postoperative analgesic effect. Thus, many adjuvants had been used to improve postoperative analgesia and decrease consumption of postoperative analgesics.

Gabapentin is a gamma aminobutyric acid analogue that is known as an anticonvulsant drug. This drug is tolerated well and has known effects on pain and anxiety.

Tramadol, a commonly used postoperative analgesic, is a synthetic centrally acting opioid analgesic. The various actions include inhibition of noradrenaline and serotonin reuptake, and also inhibition of M1 and M3 muscarinic receptors

Inclusion Criteria:

• Age 18-65 years old.
• Both sexes. American Society of Anesthesiologists (ASA) physical status I and II
• Undergoing knee arthroscopy procedures.
• under spinal anesthesia.

Exclusion Criteria:

• Cardiac patients.
• Patients with known allergy to drug of study.
• Prolonged administration of NSAIDS or other analgesics due to chronic pain of any reason.
• Cirrhosis.