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The first-line etiological workup is currently poorly codified, and some patients undergo sequential investigations. However, the reason which lead the clinician to perform subsequent exams, and the relevance of such exams, remain to be determined. The main objective of the study was to assess the relevance of a second-line workup of patients with uveitis.
The first-line etiological workup is currently poorly codified, with some patients undergoing extensive investigations, and other minimal etiological workup. In addition, some patients undergo sequential investigations. However, the reason which lead the clinician to perform subsequent exams, and the relevance of investigations performed after a first line workup remain to be determined. The main objective of the study was to assess the relevance of a second-line workup of patients with uveitis.Secondary objectives were to describe the reasons of these second-line workups, and to determine which exams were the most relevant, and the determinants of its realization.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with only one etiological workup | patients who underwent only one set of exams for etiological investigations of uveitis |
| |
| Patients without diagnostic modification subsequently to the second etiological workup | Patients who underwent a second etiological workup, independently of the results of the fist line investigations, and whose diagnosis was not modified by the second line investigations. |
| |
| Patients with diagnostic modification subsequently to the second etiological workup | Patients who underwent a second etiological workup, independently of the results of the fist line investigations, and whose diagnosis was modified by the second line investigations. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| second line investigations for uveitis etiological workup | Other | Biological, radiological or histological investigations performed after a first line etiological workup. Investigations conducted following abnormal resultats of first line exams were not considered as second line exams (e.g. : bronchoscopy performed after abrnomal CT scan). |
| Measure | Description | Time Frame |
|---|---|---|
| patients undergoing a second line etiological workup | percentage of patients undergoing a second line etiological workup | through study completion, an average of 18 months |
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Inclusion Criteria:
Exclusion Criteria:
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adult pateints with uveitis requiring at least one etiological workup.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Thomas Moulinet, MD | Contact | +3383155304 | t.moulinet@chru-nancy.fr |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22809756 | Background | Hwang DK, Chou YJ, Pu CY, Chou P. Epidemiology of uveitis among the Chinese population in Taiwan: a population-based study. Ophthalmology. 2012 Nov;119(11):2371-6. doi: 10.1016/j.ophtha.2012.05.026. Epub 2012 Jul 17. | |
| 10873978 | Background | Dandona L, Dandona R, John RK, McCarty CA, Rao GN. Population based assessment of uveitis in an urban population in southern India. Br J Ophthalmol. 2000 Jul;84(7):706-9. doi: 10.1136/bjo.84.7.706. |
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| ID | Term |
|---|---|
| D014605 | Uveitis |
| ID | Term |
|---|---|
| D014603 | Uveal Diseases |
| D005128 | Eye Diseases |
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| 16196117 | Background | Jabs DA, Nussenblatt RB, Rosenbaum JT; Standardization of Uveitis Nomenclature (SUN) Working Group. Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop. Am J Ophthalmol. 2005 Sep;140(3):509-16. doi: 10.1016/j.ajo.2005.03.057. |
| 11840433 | Background | Smith JR, Rosenbaum JT. Management of uveitis: a rheumatologic perspective. Arthritis Rheum. 2002 Feb;46(2):309-18. doi: 10.1002/art.503. No abstract available. |
| 24424168 | Background | Selmi C. Diagnosis and classification of autoimmune uveitis. Autoimmun Rev. 2014 Apr-May;13(4-5):591-4. doi: 10.1016/j.autrev.2014.01.006. Epub 2014 Jan 12. |
| 32059021 | Background | de Parisot A, Jamilloux Y, Kodjikian L, Errera MH, Sedira N, Heron E, Perard L, Cornut PL, Schneider C, Riviere S, Olle P, Pugnet G, Cathebras P, Manoli P, Bodaghi B, Saadoun D, Baillif S, Tieulie N, Andre M, Chiambaretta F, Bonin N, Bielefeld P, Bron A, Mouriaux F, Bienvenu B, Amamra N, Guerre P, Decullier E, Seve P; ULISSE group. Evaluating the cost-consequence of a standardized strategy for the etiological diagnosis of uveitis (ULISSE study). PLoS One. 2020 Feb 14;15(2):e0228918. doi: 10.1371/journal.pone.0228918. eCollection 2020. |
| 39142637 | Derived | Bana G, Angioi-Duprez K, Conart JB, Moulinet T. When and which second-line workup to perform for uveitis: a tertiary care center experience. Can J Ophthalmol. 2025 Apr;60(2):120-127. doi: 10.1016/j.jcjo.2024.07.019. Epub 2024 Aug 11. |