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It is important to decrease the time-to-loss of consciousness and anesthetics dose of remimazolam for general anesthesia induction. We will evaluate the effect of binaural sound for general anestheia induction using remimazolam infusion.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| I (Binaural) | Experimental | Binaural sound using headphone will be applied. |
|
| II (Placebo) | Placebo Comparator | Only headphone without sound will be applied. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Binaural sound | Procedure | Binaural sound: Binaural sound will be applied. |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Remimazolam dose for no response to voice | Remimazolam dose for no response to voice will be measured at anesthesia day 0. | At anesthesia day 0 |
| Measure | Description | Time Frame |
|---|---|---|
| Remimazolam dose for no eye lash reflex | Remimazolam dose for no eye lash reflex will be measured at anesthesia day 0. | At anesthesia day 0 |
| Remimazolam dose for patient state index 50 | Remimazolam dose for patient state index 50 will be measured at anesthesia day 0. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hyun-Chang Kim | Contact | 82-2-2224-3919 | onidori@yuhs.ac |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| GangnamSeveranceHospital | Recruiting | Seoul | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41911215 | Derived | Kim HC, Sohn JY, Kim MH, Kim YJ, Chang CH, Seo JH. Preoperative binaural beats reduce remimazolam dosage and enhance safety in anesthesia induction: A randomized controlled trial. PLoS One. 2026 Mar 30;21(3):e0345960. doi: 10.1371/journal.pone.0345960. eCollection 2026. |
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| ID | Term |
|---|---|
| D011471 | Prostatic Neoplasms |
| D047708 | Myofibroma |
| ID | Term |
|---|---|
| D005834 | Genital Neoplasms, Male |
| D014565 | Urogenital Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| Placebo |
| Procedure |
Only headphone without sound will be applied. |
|
| At anesthesia day 0 |
| Anxiety level | Anxiety level will be evaluated using viosual analogue scale at anesthesia day 0 (at arrival of preanesthetic room and operating room). | At anesthesia day 0 |
| Patient state index electroencephalography | Patient state index electroencephalography will be evaluated at anesthesia day 0 | At anesthesia day 0 |
| D005832 |
| Genital Diseases, Male |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D011469 | Prostatic Diseases |
| D052801 | Male Urogenital Diseases |
| D009372 | Neoplasms, Connective Tissue |
| D018204 | Neoplasms, Connective and Soft Tissue |
| D009370 | Neoplasms by Histologic Type |
| D003240 | Connective Tissue Diseases |
| D017437 | Skin and Connective Tissue Diseases |