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Patients with ischemic stroke in the posterior circulation continue to have high rates of mortality and disability, even with aggressive treatment. We wanted to evaluate preoperative imaging to screen patients with a good prognosis from mechanical embolization. We assess the degree of ischemia by defining the pons-midbrain-medulla index (PMMI) and correlate the preoperative PMMI with the clinical prognosis of postoperative patients to verify the validity of PMMI in predicting the clinical prognosis of patients with embolization.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Endovascular therapy | Timely thrombectomy for acute ischemic stroke patients with large vessel occlusion by either stent retriever, thrombus aspiration, others, or combination methods. |
| |
| Best medical management | Patients enrolled in this group received the best medical management. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Endovascular Therapy | Procedure | Endovascular therapy, as an adjunct to standard stroke therapy, may be beneficial for a very select population of patients who present with an acute ischemic stroke and have a proven large, proximal occlusion on imaging. Endovascular therapy includes any one or more of the following: Intra-arterial thrombolytic therapy, aspiration, stent retrieval, or a combination of multiple mechanical devices |
| Measure | Description | Time Frame |
|---|---|---|
| Modified ranking scale (mRS) at 90 days | A 0-6 scale running from perfect health without symptoms to death. | 90 days |
| Measure | Description | Time Frame |
|---|---|---|
| Mortality within 90 days | mortality of any causes. | 90 days |
| Measure | Description | Time Frame |
|---|---|---|
| National Institutes of Health Stroke Scale (NIHSS) scores at 90 days | The NIHSS is composed of 11 items, each of which scores a specific ability between a 0 and 4. For each item, a score of 0 typically indicates normal function in that specific ability, while a higher score is indicative of some level of impairment. The individual scores from each item are summed in order to calculate a patient's total NIHSS score. The maximum possible score is 42, with the minimum score being a 0. |
Inclusion Criteria:
Exclusion Criteria:
1.Patiens can not meet the MRI examination conditions(with absolute and relative contraindications).
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All acute ischemic strvoke patients with vertebrobasilar artery occlusion.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ming Wei, PhD | Contact | 13502182903 | drweiming@163.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tianjin Medical University General Hospital | Recruiting | Tianjin | Tianjin Municipality | 300052 | China |
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|
| 90 days |
| Occurrence of periprocedural complications | Periprocedural complications include any intracranial hemorrhage, cerebral edema, brain herniation and pneumonia. | 90 days |
| pc-ASPECT (posterior circulation Alberta Stroke Program Early CT score) | pc-ASPECTS is a 10-point quantitative topographic CT scan score used in patients with posterior circulation stroke. | 0 days |
| The Sencond Hospital of Tianjin Medical University | Recruiting | Tianjin | Tianjin Municipality | 300211 | China |
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| Tianjin Huanhu Hospital | Recruiting | Tianjin | Tianjin Municipality | 300222 | China |
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| Beijing University Binhai Hospital | Recruiting | Tianjin | Tianjin Municipality | 300450 | China |
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