Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. For clinical operationalization, organ dysfunction can be represented by an increase in the Sequential Organ Failure Assessment (SOFA) score of 2 points or more, which is associated with an in-hospital mortality greater than 10%. pancreatic stone protein has been studied as biomarker of sepsis and results suggests that it has higher diagnostic performance. The main objective of this study is to identify ability of pancreatic stone protein (PSP) as a new biomarker for diagnosis of urosepsis in Intensive Care Units comparison to other biomarkers and its role as a prognostic marker for mortality

Inclusion Criteria:

• Adult ill patients at the ICU aged more than 18 years old who at risk of urosepsis.
• Both males and females.

Exclusion Criteria:

• - Age less than 18 years.
• Patients with a clinical diagnosis of sepsis at admission.
• Critically ill septic patients with a diagnosis other than urosepsis.
• Critically ill patients who were diagnosed to have urosepsis outside Ain Shams university intensive care and transferred to it.
• Malignant tumor patients.
• Uremic patients undergoing dialysis.

patients who was admitted in intensive care units in Ain Shams University and had risk factors for urosepsis.