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| Name | Class |
|---|---|
| University of Zurich | OTHER |
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The purpose of this study is to determine the diagnostic accuracy of Pancreatic Stone Protein (PSP) in predicting patient outcomes with suspected peritonitis in the Intensive Care Unit after abdominal surgery and compare PPS with other blood parameters, including C-Reactive Protein (CRP), White Cell Count (WCC), Interleucin-6 (IL-6) and Procalcitonin (PCT).
Peritonitis is a severe complication after abdominal surgery. Patients admitted at the Intensive Care Unit (ICU) following surgery bear the risk of localized infection, sepsis or septic shock. Prevention or early detection of such events is important to intervene with an appropriate therapeutic action and avoid risking a potentially life-threatening situation. White blood cell counts (WCC) and C-Reactive Protein (CRP), Interleucin-6 (IL-6) and Procalcitonin (PCT) have all been promising parameters, however, they are useful only in selective cases and have a limited diagnostic accuracy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Admission to the Intensive Care Unit (ICU) after abdominal surgery without suspicion / evidence of peritonitis. |
| |
| Peritonitis | Admission to the Intensive Care Unit (ICU) after abdominal surgery with suspicion / evidence of peritonitis |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| All abdominal surgical procedures | Procedure | Laparotomy, Laparoscopy |
|
| Measure | Description | Time Frame |
|---|---|---|
| Localization of Peritonitis | Localised vs. diffused. A clinical finding intra-operatively and/or radiologically (i.e. CT or MRI) | up to 2 months |
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Inclusion Criteria:
Exclusion Criteria:
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Primary care clinics
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| Name | Affiliation | Role |
|---|---|---|
| Walter Halangk, PhD | University of Magdeburg, Department of General, Visceral and Vascular Surgery, Leipziger Str. 44, DE-39120, Magdeburg, Germany | Principal Investigator |
| Hans-Ulrich Schulz, MD | University of Magdeburg, Department of General, Visceral and Vascular Surgery, Leipziger Str. 44, DE-39120, Magdeburg, Germany | Principal Investigator |
| Rolf Graf, PhD | University Hospital Zurich, Department of Surgery, Raemistrasse 100, CH-8091, Zurich, Switzerland | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Magdeburg | Magdeburg | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23399938 | Derived | Gukasjan R, Raptis DA, Schulz HU, Halangk W, Graf R. Pancreatic stone protein predicts outcome in patients with peritonitis in the ICU. Crit Care Med. 2013 Apr;41(4):1027-36. doi: 10.1097/CCM.0b013e3182771193. |
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| ID | Term |
|---|---|
| D010538 | Peritonitis |
| D018805 | Sepsis |
| D009102 | Multiple Organ Failure |
| D003643 | Death |
| D006967 | Hypersensitivity |
| ID | Term |
|---|---|
| D059413 | Intraabdominal Infections |
| D007239 | Infections |
| D010532 | Peritoneal Diseases |
| D004066 | Digestive System Diseases |
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| ID | Term |
|---|---|
| D013514 | Surgical Procedures, Operative |
| D007440 | Intubation |
| D007442 | Intubation, Intratracheal |
| D014139 | Tracheostomy |
| D014965 | X-Rays |
| ID | Term |
|---|---|
| D013812 | Therapeutics |
| D008919 | Investigative Techniques |
| D058109 | Airway Management |
| D010030 | Ostomy |
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Whole blood, serum, plasma
| Intubation | Procedure | Ventilatory support |
|
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| Imaging | Radiation | Abdominal ultrasound Computer Tomography Magnetic Resonance Imaging |
|
|
| D018746 |
| Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012769 | Shock |
| D007154 | Immune System Diseases |
| D013517 |
| Otorhinolaryngologic Surgical Procedures |
| D019616 | Thoracic Surgical Procedures |
| D060733 | Electromagnetic Radiation |
| D055590 | Electromagnetic Phenomena |
| D060328 | Magnetic Phenomena |
| D055585 | Physical Phenomena |
| D011827 | Radiation |
| D011839 | Radiation, Ionizing |