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| Name | Class |
|---|---|
| IRCCS Policlinico S. Donato | OTHER |
| Mitera Children's Hospital, Athens Heart Surgery Institute, Greece | UNKNOWN |
| Ospedale Civile Ca' Foncello | OTHER |
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Anomalous aortic origin of a coronary artery (AAOCA) is a group of rare congenital heart defects with various clinical presentations. The lifetime-risk of an individual living with AAOCA is unknown, and data from multicentre registries are urgently needed to adapt current recommendations and guide optimal patient management. The European Registry for AAOCA (EURO-AAOCA) aims to assess differences with regard to AAOCA management between centres.
EURO AAOCA study database on management for "ANOMALOUS AORTIC ORIGIN OF CORONARY ARTERIES.
This is a simple Excel database in 8 sections (see below). The patient's identification (ID) should be anonymous, and can be decided by each center; the investigators suggest to enclose Centre ID number (which is communicated by the leading center) and a sequential number or date of birth (dd/mm/yy).
If no procedure has been done for the patients , it is required to the "PERIPROCEDURAL, SURGICAL DETAILS" and "POSTPROCEDURAL" data sheets (which are outlined in RED). In the "PERIPROCEDURAL" sheet, the participants may refer either to the surgical or non surgical procedure.
Baseline and long term clinical evaluation sections must be completed for all patients.
In the database, there are lists of multiple different variables which are summarized in tables enclosed in the section, in which each item corresponds to a number.
EURO AAOCA Study DATABASE sections
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| adult > 30 years | All adult patient > 30 yrs undergoing diagnosis (incidental or not) of anomalous aortic origin of coronary arteries |
| |
| Juvenile < 30 yrs | All young patient <30 yrs undergoing diagnosis (incidental or not) of anomalous aortic origin of coronary arteries |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| unroofing or other surgery if needed | Procedure | unroofing of coronary artery |
|
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of Symptoms at diagnosis and after surgery | The study will assess the presence of symptoms (angina, chest pain, distress, sudden cardiac death-SCD, syncope, aborted SCD) at diagnosis, and after eventual surgical repair, to assess incidence of symptoms in patients with this anomaly and effectiveness of surgery in removing symptoms. | 5 years |
| Incidence of postoperative adverse events | The study will assess the incidence of operative death and adverse events after surgery (in those who undergo surgery). | 5 years |
| Incidence of adverse events at follow up | The study will assess the incidence of death and adverse events at clinical follow up either in patients who required a surgical repair or in those who did not undergo surgery because of lack of indications. | 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of any arrhythmias at Follow up | The study will assess the incidence of any (mostly ventricular) arrhythmias in all patients, either surgical or non surgical | 5 years |
| Rate of return to unrestricted competitive sport |
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Inclusion Criteria:
Exclusion Criteria:
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all patients undergoing incidental or not diagnosis of AAOCA
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Massimo Padalino, MD PhD | Contact | 00393408922564 | massimo.padalino@unipd.it | |
| Chris Grani, MD PhD | Contact | 0041788158858 | christoph.graeni@insel.ch |
| Name | Affiliation | Role |
|---|---|---|
| Massimo Padalino, MD PhD | University of Padova | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Massimo Padalino | Recruiting | Padova | PD | 35128 | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34055925 | Result | Padalino MA, Jegatheeswaran A, Blitzer D, Ricciardi G, Guariento A. Surgery for Anomalous Aortic Origin of Coronary Arteries: Technical Safeguards and Pitfalls. Front Cardiovasc Med. 2021 May 12;8:626108. doi: 10.3389/fcvm.2021.626108. eCollection 2021. | |
| 36205254 | Result | Bigler MR, Kadner A, Raber L, Ashraf A, Windecker S, Siepe M, Padalino MA, Grani C. Therapeutic Management of Anomalous Coronary Arteries Originating From the Opposite Sinus of Valsalva: Current Evidence, Proposed Approach, and the Unknowing. J Am Heart Assoc. 2022 Oct 18;11(20):e027098. doi: 10.1161/JAHA.122.027098. Epub 2022 Oct 7. |
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The anonymized demographic and clinical data underlying this study can be shared on reasonable request to the principal investigator
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| University Hospital, Ghent |
| OTHER |
| Guy's and St Thomas' NHS Foundation Trust | OTHER |
| Azienda Ospedaliera Universitaria Integrata Verona | OTHER |
| University Medical Center Groningen | OTHER |
| Hospital Universitario La Paz | OTHER |
| Cliniques universitaires Saint-Luc- Université Catholique de Louvain | OTHER |
| Insel Gruppe AG, University Hospital Bern | OTHER |
| Azienda Ospedaliero-Universitaria di Parma | OTHER |
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The study will assess the rate of return to unrestricted sport and competitive sport activity in all patients, either surgical or non surgical
| 5 years |
| Christopher Grani | Recruiting | Bern | Switzerland |
|
| 35757950 | Result | Ponzoni M, Frigo AC, Padalino MA. Surgery for Anomalous Aortic Origin of a Coronary Artery (AAOCA) in Children and Adolescents: A Meta-Analysis. World J Pediatr Congenit Heart Surg. 2022 Jul;13(4):485-494. doi: 10.1177/21501351221095424. |
| 35224033 | Result | Grani C, Padalino MA. Editorial: Coronary Artery Anomalies: A 2020 Review. Front Cardiovasc Med. 2022 Feb 10;9:776951. doi: 10.3389/fcvm.2022.776951. eCollection 2022. No abstract available. |
| 34136540 | Result | Thiene G, Frescura C, Padalino M, Basso C, Rizzo S. Coronary Arteries: Normal Anatomy With Historical Notes and Embryology of Main Stems. Front Cardiovasc Med. 2021 May 31;8:649855. doi: 10.3389/fcvm.2021.649855. eCollection 2021. |
| 30897195 | Result | Padalino MA, Franchetti N, Hazekamp M, Sojak V, Carrel T, Frigiola A, Lo Rito M, Horer J, Roussin R, Cleuziou J, Meyns B, Fragata J, Telles H, Polimenakos AC, Francois K, Veshti A, Salminen J, Rocafort AG, Nosal M, Vedovelli L, Guariento A, Vida VL, Sarris GE, Boccuzzo G, Stellin G. Surgery for anomalous aortic origin of coronary arteries: a multicentre study from the European Congenital Heart Surgeons Associationdagger. Eur J Cardiothorac Surg. 2019 Oct 1;56(4):696-703. doi: 10.1093/ejcts/ezz080. |
| ID | Term |
|---|---|
| D006330 | Heart Defects, Congenital |
| D016757 | Death, Sudden, Cardiac |
| D004194 | Disease |
| D001145 | Arrhythmias, Cardiac |
| ID | Term |
|---|---|
| D018376 | Cardiovascular Abnormalities |
| D002318 | Cardiovascular Diseases |
| D006331 | Heart Diseases |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D006323 | Heart Arrest |
| D003645 | Death, Sudden |
| D003643 | Death |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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