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As the body ages, the skin experiences natural changes in structure and composition. These changes may manifest visibly as increased skin dryness, wrinkling, and a loss of firmness/elasticity. In this double-blind, randomized, placebo-controlled trial, the investigators will recruit healthy men and women with mild to moderate signs of skin aging and randomly assign them to either receive a HyaCera™ or placebo for 12 weeks. The investigators will perform a series of objective and subjective measurements to assess changes in skin condition. The investigators hypothesize that consumption of HyaCera™ leads to improvements in the general condition of the skin including skin hydration, crow's feet wrinkling, and other skin aging parameters.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Active | Active Comparator | Participants receive 1 HyaCera™ capsule orally once daily for 12 weeks |
|
| Placebo | Placebo Comparator | Participants receive 1 placebo capsule orally once daily for 12 weeks |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| HyaCera™ | Dietary Supplement | 1 Ritual HyaCera capsule once daily |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Crow's Feet Wrinkles | Degree of crow's feet wrinkling will be measured via Visioscan® | at week 0, Week 4, Week 8, and Week 12 |
| Skin Smoothness | Skin smoothness will be measured via Visioscan® | at week 0, Week 4, Week 8, and Week 12 |
| Skin Hydration | Skin surface hydration will be measured via Corneometer® 825 | at week 0, Week 4, Week 8, and Week 12 |
| Measure | Description | Time Frame |
|---|---|---|
| Skin Elasticity | Skin elasticity will be measured via Cutometer® MPA 580 | at week 0, Week 4, Week 8, and Week 12 |
| Skin Barrier Function | Skin barrier function (as transepidermal water loss) will be measured via Tewameter® |
| Measure | Description | Time Frame |
|---|---|---|
| Dermatologist grading of skin condition | Visual and tactile dermatologist evaluation of skin condition (fine lines in the crow's feet area, wrinkles in the crow's feet area, skin dryness, skin radiance, and skin smoothness) based on 10-point grading scale (with 0 being no signs of aging and 9 being the most severe) | at week 0, Week 4, Week 8, and Week 12 |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Princeton Consumer Research | Raritan | New Jersey | 08869 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41071523 | Derived | Grier-Welch AM, Vance AY, Alamdari N, Sharafi M. Efficacy of an Oral Skincare Supplement on Skin Aging: A 12-Week Randomized, Double-Blind, Placebo-Controlled Trial. Dermatol Ther (Heidelb). 2025 Dec;15(12):3689-3702. doi: 10.1007/s13555-025-01556-2. Epub 2025 Oct 10. |
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Healthy men and women with mild to moderate signs of skin aging will be randomly assigned to either receive a Ritual HyaCera or placebo for 12 weeks
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Neither the participants nor the investigators will know the group assignment. Supplements will be prepared by the sponsor and marked with unidentifiable ID numbers before being sent to study site.
| Placebo |
| Dietary Supplement |
1 placebo capsule once daily |
|
| at week 0, Week 4, Week 8, and Week 12 |
| Skin Scaliness | Skin scaliness will be measured via Visioscan® | at week 0, Week 4, Week 8, and Week 12 |
| Self-evaluation of perceived changes in skin condition | Self-evaluation of changes in skin condition and signs of skin aging (i.e. fine lines & wrinkles, skin texture, skin smoothness, skin plumpness, skin glow/radiance, skin hydration, skin elasticity, skin redness, skin itchiness) using a 5-point Likert scale (options: much worse, somewhat worse, stayed the same, somewhat better, much better) | at week 0, Week 4, Week 8, and Week 12 |