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To evaluate the safety and effectiveness of PRP injection therapy in the repair of osteoarthritis and periarticular soft tissue injury through a single-center, exploratory clinical study, and to provide a more reliable basis for the treatment of joint injury.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Preoperative | No Intervention | ||
| postoperative (6 weeks) | Experimental | The patients were injected with PRP. |
|
| postoperative (3 months) | Experimental | The patients were injected with PRP. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sodium hyaluronate injection | Drug | The control group was injected into the joint cavity with sodium hyaluronate injection.. |
|
| Measure | Description | Time Frame |
|---|---|---|
| X-ray | The postoperative plain X-ray film was utilized for the assessment of knee joint deformity, stenosis of the joint space, and hyperplasia of osteophytes. | pre-operation,3 weeks after treatment, 6 months after treatment |
| CT | The application of three-dimensional CT scan for the assessment of articular cartilage defects. | pre-operation,3 weeks after treatment, 6 months after treatment |
| MRI | The injury of ligaments, meniscus, and the knee joint was assessed using MRI. | pre-operation,3 weeks after treatment, 6 months after treatment |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yanyan Jia | Contact | +862984771794 | xiyyllwyh@163.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Xijing Hospital | Recruiting | Xi'an | Shannxi | 710034 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36326886 | Background | Ramos-Gonzalez G, Salazar L, Wittig O, Diaz-Solano D, Cardier JE. The effects of mesenchymal stromal cells and platelet-rich plasma treatments on cutaneous wound healing. Arch Dermatol Res. 2023 May;315(4):815-823. doi: 10.1007/s00403-022-02451-y. Epub 2022 Nov 3. | |
| 34414200 | Background | Zhang Y, Xing F, Luo R, Duan X. Platelet-Rich Plasma for Bone Fracture Treatment: A Systematic Review of Current Evidence in Preclinical and Clinical Studies. Front Med (Lausanne). 2021 Aug 3;8:676033. doi: 10.3389/fmed.2021.676033. eCollection 2021. |
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| ID | Term |
|---|---|
| D010003 | Osteoarthritis |
| ID | Term |
|---|---|
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |
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| ID | Term |
|---|---|
| D006820 | Hyaluronic Acid |
| ID | Term |
|---|---|
| D006025 | Glycosaminoglycans |
| D011134 | Polysaccharides |
| D002241 | Carbohydrates |
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