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Autologous platelet-secreted growth factors (GFs) may have therapeutic effects in osteoarthritis (OA) capsular joints via multiple mechanisms. The aim is to examine the effect of a platelet-derived preparation rich in growth factors (PRGFs) in OA of the knee.
Autologous platelet-secreted growth factors (GFs) may have therapeutic effects in osteoarthritis (OA) capsular joints via multiple mechanisms. The investigators aim is to examine the effect of a platelet-derived preparation rich in growth factors(PRGFs) in OA of the knee, using parameters of pain, function, quality of life and safety.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Platelet Rich Plasma (Preparation Rich in Growth Factors) | Experimental | intra articular injection 6ml of platelet-derived preparation rich in growth factors |
|
| Hyaluronic acid | Active Comparator | Drug: hyaluronic acid 20 mg / 2 ml Other Name: Arthrease |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Platelet Rich Plasma (Preparation Rich in Growth Factors) | Biological | intra articular injection 6ml |
|
| Measure | Description | Time Frame |
|---|---|---|
| Improvement in pain, function, quality of life and activity level in knee osteoarthritis | Improvement in pain, function, quality of life, activity level - using scores adapted to measure these parameters in knee osteoarthritis. | 1 -2 years |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Lior Laver, MD | Contact | +972-50-8464466 | laver17@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Lior Laver, MD | Meir Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Meir Medical Center | Kfar Saba | Israel |
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| ID | Term |
|---|---|
| D020370 | Osteoarthritis, Knee |
| D010003 | Osteoarthritis |
| ID | Term |
|---|---|
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |
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| ID | Term |
|---|---|
| D036341 | Intercellular Signaling Peptides and Proteins |
| D006820 | Hyaluronic Acid |
| ID | Term |
|---|---|
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |
| D011506 | Proteins |
| D001685 | Biological Factors |
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|
| Hyaluronic acid | Drug | Intra articular injections: 20 mg / 2 ml |
|
|
| D006025 |
| Glycosaminoglycans |
| D011134 | Polysaccharides |
| D002241 | Carbohydrates |