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The goal of this study is to compare the clinical outcomes of using NPWT dressing versus conventional dressing in improving flaps outcome
The cases will be divided into 3 major study groups:
1st group will be managed with high negative pressure wound therapy The 2nd group will be managed with low negative pressure wound therapy The 3rd group will be managed with conventional dressing
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High negative pressure group | Active Comparator | A high negative pressure amplitude, (75- 125 mmHg) on continuous mode, is applied over the flaps |
|
| Low negative pressure group | Active Comparator | A low negative pressure amplitude, (50- <75 mmHg) on intermittent mode, is applied over the flaps |
|
| Control group | Placebo Comparator | Conventional dressing is applied over the flaps |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| NPWT | Device | the NPWT dressing applied to fasciocutaneous flap |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of Participants with primary healing | Healing by epithelization without the need for secondary intervention | 2 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Number of Participants with flap Edema | flap edema clinical & radiological assessment | 1 week |
| Number of Participants with flap Congestion | flap congestion clinical assessment |
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Inclusion Criteria:
- Adult patients skin and soft tissue defects that need flap coverage
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Aswan University Hospital | Aswān | 81511 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40123035 | Derived | Elbanna OH, Eldine AS, Sayed AM, Mousa AK. The efficacy and safety of different negative-pressure wound therapy gradients on flaps outcomes. Updates Surg. 2025 Dec;77(8):2643-2651. doi: 10.1007/s13304-025-02156-7. Epub 2025 Mar 23. |
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Negative pressure wound therapy (vacuum-assisted wound closure) for postoperative flap care
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| Conventional dressing | Other | Conventional dressing ( topical care ) applied to fasciocutaneous flap |
|
| 1 week |
| Number of Participants with flap Ischemia | flap ischemia clinical assessment | 1 week |
| Number of Participants with flap infection | surgical site infection | 2 weeks |