Aim: The aim of the current study was to compare and correlate gingival crevicular fluid (GCF) fetuin-A levels and high sensitivity C-reactive protein (hs-CRP) levels in non-diabetic periodontitis patients and type 2 diabetic periodontitis patients with healthy subjects and revealing its possible role in diagnosis of periodontal disease.

Methodology: Forty-five periodontitis stage III patients categorized into 3 groups according to whether having type II diabetes mellitus or not were compared to systemically and periodontally healthy participants in this investigation. Clinical parameters for all groups were recorded. Assessment of GCF levels of fetuin A and hs-CRP were done to all enrolled participants utilizing an enzyme linked immune-sorbent assay (ELISA) kit. Receiver operating characteristic (ROC) curve was performed to reveal sensitivity, specificity, predictive value and diagnostic accuracy of the markers used.

Inclusion Criteria:

• both gender periodontitis stage III

Exclusion Criteria:

1. Smoking,
2. Systemic diseases (except DM in group B),
3. Periodontitis patients having periodontal treatment recently (past 6 months),
4. Pregnancy, lactation, contraceptive pills,
5. Anti-inflammatory/ immunosuppressive drugs.

individuals recruited from outpatient clinic of periodontology department