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This study used a single-center, randomized, open-label, three-period, crossover trial design. Fifteen healthy subjects were planned to be enrolled, and the subjects were randomly assigned to any group A, B and C in the order of screening, with 5 cases in each group
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Treatment group A | Experimental | Take Herombopag Olamine Tablets 7.5mg 4h after high-fat meal in the first cycle, and take Herombopag Olamine Tablets 7.5mg on an empty stomach in the second cycle. In the third cycle, take Herombopag Olamine Tablets 7.5mg 30min after a standard meal; |
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| Treatment group B | Experimental | Take Herombopag Olamine Tablets 7.5mg on an empty stomach in the first cycle, and take Herombopag Olamine Tablets 7.5mg 30min after a standard meal in the second cycle. In the third cycle, Herombopag Olamine Tablets 7.5mg were taken 4h after a high-fat meal |
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| Treatment group C | Experimental | Take Herombopag Olamine Tablets 7.5mg 30min after standard meal in the first cycle, and take Herombopag Olamine Tablets 7.5mg 4h after high-fat meal in the second cycle. In the third cycle, Herombopag Olamine Tablets 7.5mg were taken on an empty stomach |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Herombopag Olamine Tablets | Drug | Three Herombopag Olamine Tablets is administered to healthy subjects. |
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| Measure | Description | Time Frame |
|---|---|---|
| PK parameters:Cmax | 0hour to 120hours after the last dosing | |
| PK parameters:AUC0-t | 0hour to 120hours after the last dosing | |
| PK parameters:AUC0-∞ | 0hour to 120hours after the last dosing |
| Measure | Description | Time Frame |
|---|---|---|
| PK parameters:Tmax | 0hour to 120hours after the last dosing | |
| PK parameters:t1/2 | 0hour to 120hours after the last dosing | |
| PK parameters:CL/F |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sheng Feng | Contact | +86-0518-82342973 | sheng.feng@hengrui.com | |
| Hongda Lin | Contact | +86-0518-82342973 | hongda.lin@hengrui.com |
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| 0hour to 120hours after the last dosing |
| PK parameters:V/F | 0hour to 120hours after the last dosing |
| Incidence and severity of adverse events (AEs) | from screening to 120 hours after the last dosing |