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It is a single-center randomized controlled trial that aims to figure out the effect of the hypotension prediction index (HPI) on the prevention of acute kidney injury (AKI) after robot-assisted urological surgery. The primary hypothesis is that HPI software guidance prevents postoperative AKI by reducing the duration and severity of intraoperative hypotension (IOH).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HPI | Experimental | Managing intraoperative hemodynamic condition under the HPI guidance |
|
| Control | No Intervention | Managing intraoperative hemodynamic condition with standard anesthesia care (blinding the HPI monitor screen) |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| BP management with HPI guidance | Device | The hemodynamic condition of the HPI group will be managed by HPI guidance which is derived by arterial pressure waveform information, including Eadyn, SVV, dP/dt. |
| Measure | Description | Time Frame |
|---|---|---|
| Acute kidney injury | Occurrence of acute kidney injury after robotic urological surgery | Seven day after the operation |
| Measure | Description | Time Frame |
|---|---|---|
| Depth and duration of hypotension | Depth and duration of hypotension will be assessed by calculating time weighted average (TWA) of hypotension under mean arterial pressure under 65 mmHg during the operation | From applying HPI (hypotension prediction index) monitor to the arterial line to the end of the anesthesia |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ewha Womans University Mokdong Hospital | Recruiting | Seoul | 07985 | South Korea |
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| ID | Term |
|---|---|
| D011471 | Prostatic Neoplasms |
| D007680 | Kidney Neoplasms |
| D014570 | Urologic Diseases |
| ID | Term |
|---|---|
| D005834 | Genital Neoplasms, Male |
| D014565 | Urogenital Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| Hypotension prediction index |
Time weighted average of hypotension prediction index during the operation |
| From applying HPI (hypotension prediction index) monitor to the arterial line to the end of the anesthesia |
| Biomarkers | Biomarkers for early detection of AKI - Cystacin C, KIM-1 | Baseline, immediate postop |
| D005832 |
| Genital Diseases, Male |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D011469 | Prostatic Diseases |
| D052801 | Male Urogenital Diseases |
| D014571 | Urologic Neoplasms |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D007674 | Kidney Diseases |