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It is a single-center randomized controlled trial that aims to figure out the effect of the hypotension prediction index (HPI) on the prevention of acute kidney injury (AKI) after radical cystectomy. The primary hypothesis is that HPI software guidance prevents postoperative AKI by reducing the duration and severity of intraoperative hypotension (IOH).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HPI group | Experimental | Managing intraoperative hemodynamic condition under the HPI guidance |
|
| Standard care group | No Intervention | Managing intraoperative hemodynamic condition with standard anesthesia care (blinding the HPI monitor screen) |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| BP management with HPI guidance | Device | The hemodynamic condition of the HPI group will be managed by HPI guidance which is derived by arterial pressure waveform information, including Eadyn, SVV, dP/dt. |
| Measure | Description | Time Frame |
|---|---|---|
| Acute kidney injury | Occurrence of acute kidney injury after radical cystectomy | Seven day after the operation |
| Measure | Description | Time Frame |
|---|---|---|
| Depth and duration of hypotension | Depth and duration of hypotension will be assessed by calculating time weighted average (TWA) of hypotension under mean arterial pressure under 65 mmHg during the operation | From applying HPI (hypotension prediction index) monitor to the arterial line to the end of the anesthesia |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Sooyoung Cho, MD, PhD | Ewha Womans University Mokdong Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ewha Womans University Mokdong Hospital | Seoul | 07985 | South Korea |
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| ID | Term |
|---|---|
| D001749 | Urinary Bladder Neoplasms |
| ID | Term |
|---|---|
| D014571 | Urologic Neoplasms |
| D014565 | Urogenital Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| Hypotension prediction index |
Time weighted average of hypotension prediction index during the operation |
| From applying HPI (hypotension prediction index) monitor to the arterial line to the end of the anesthesia |
| D052776 |
| Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D001745 | Urinary Bladder Diseases |
| D014570 | Urologic Diseases |
| D052801 | Male Urogenital Diseases |