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The overarching goal of the current study is to investigate the effect of one acute bout of exercise on the brain insulin responsiveness in a cross-over study design. To this end, investigators will compare the effect of two single endurance exercise sessions with different intensities, namely moderate intensity continuous training (MICT) and high-intensity-interval-training (HIIT), which will be performed in a randomized order. This will be compared to a waiting control condition.
Investigate one acute bout of exercise on the brain insulin responsiveness using functional magnetic resonance imaging in combination with intranasal insulin in healthy participants of normal-weight and overweight/obesity. Two single endurance exercise sessions with different intensities will be evaluated, namely moderate intensity continuous training (MICT) and high-intensity interval training (HIIT). This will be compared to a waiting control condition. In a cross-over design, investigators will compare cerebral response from before to after intranasal insulin administration after a single bout of HIIT or MICT compared to a control condition without exercise. Cerebral response is defined as the cerebral blood flow and resting state functional connectivity in response to intranasal insulin. Secondary outcomes include changes in blood metabolites and proteins and changes in eating behavior.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| moderate intensity continuous training | Experimental |
| |
| High-intensity interval training | Experimental |
| |
| Waiting condition | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| single bout of moderate intensity continuous training (MICT) | Behavioral | the MICT consists of 60 min continuous cycling |
|
| Measure | Description | Time Frame |
|---|---|---|
| Cerebral response after intranasal insulin administration | The resting-state cerebral response from before to after intranasal insulin administration after a single bout of HIIT or MICT exercise compared to a control condition without exercise (i.e., waiting control) | 1 hour after exercise or waiting control |
| Measure | Description | Time Frame |
|---|---|---|
| Task based brain activation after high-intensity-interval-training (HITT) or moderate intensity continuous training (MICT) compared to control condition | Food cue reactivity after a single bout of HIIT or MICT exercise compared to a control condition without exercise (i.e., waiting control) | 1 hour after exercise or waiting control |
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Inclusion Criteria:
Exclusion Criteria
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Stephanie Kullmann, PhD | Contact | 0049707129 | 87703 | stephanie.kullmann@med.uni-tuebingen.de |
| Name | Affiliation | Role |
|---|---|---|
| Andreas L. Birkenfeld, MD | Institute for Diabetes research and Metabolic Diseases at the University of Tubingen | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Clinic Tübingen, Department of Internal Medicine IV | Recruiting | Tübingen | 72076 | Germany |
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| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| D009765 | Obesity |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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In a cross-over design, we will compare cerebral response from before to after intranasal insulin administration after a single bout of HIIT or MICT compared to a control condition without exercise.
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| single bout of High Intensity Interval Training (HIIT) | Behavioral | HIIT consists of 10-min warm-up at the power output corresponding to 50% peak power output (PPO), 4 x 4-min intervals at a power output corresponding to 75% PPO with a 4-min active resting period at 30% PPO to recover |
|
| waiting control | Behavioral | sitting in a waiting room for 60 min |
|
| Subjective feeling of hunger and food craving |
Questionnaire assessment before and after exercise or waiting control. |
| baseline, 1 hour after breakfast, 1 hour, 2 hour, 3 hours after exercise or waiting control |
| Changes in Blood-brain barrier integrity | Robust multiple echo-time arterial spin labelling based Blood Brain Barrier integrity measurements from before to after intranasal insulin administration after a single bout of HIIT or MICT exercise compared to a control condition without exercise (i.e., waiting control) | 1 hour after exercise or waiting control |
| Performance during cognitive tasks | Cambridge Cognition Tests Battery to assess memory and inhibitory control using the paired associates learning task, the pattern recognition memory task and the stop-signal reaction task. | 1 hour after exercise or waiting control |
| Changes in exerkines from plasma samples | Blood sampling at 5 time points before and after a single bout of HIIT or MICT exercise compared to a control condition without exercise (i.e., waiting control) | baseline, 1 hour after breakfast, 1 hour, 2 hour, 3 hours after exercise or waiting control |
| Change in incretins from plasma samples | Blood sampling at 5 time points before and after a single bout of HIIT or MICT exercise compared to a control condition without exercise (i.e., waiting control) | baseline, 1 hour after breakfast, 1 hour, 2 hour, 3 hours after exercise or waiting control |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001519 | Behavior |