Insulin Sensitivity of the Human CNS System: fMRI Study With Intranasal Insulin Application

Insulinsensitivität Des Menschlichen Zentralnervensystems: Kernspintomographische Untersuchung Mit Intranasaler Gabe Von Insulin

The purpose of the study is to investigate whether insulin sensitivity and insulin resistance of the human brain is comparable in all insulin sensitive parts of the brain and whether correlates to other phenotypic information (i.e. whole body insulin sensitivity, BMI, age) of the study participants.

Inclusion Criteria:

• Normal routine blood works
• for women: negative pregnancy test
• healthy

Exclusion Criteria:

• Type 2 diabetes
• pregnancy
• acute or chronic diseases
• Pacemakers
• Artificial heart valves
• Metal prostheses
• Implanted magnetic metal parts (screws, ...)
• Metal fragments
• Braces
• insulin pumps
• Tattoos
• claustrophobia
• reduced temperature sensation and / or increased sensitivity to warming of the body
• Ear disease or an increased sensitivity to loud noises