NAC vs Placebo on Opioid Use for Hysterectomy

A Trial Evaluating the Impact of N-acetylcysteine on Opioid Use in Patients Undergoing a Hysterectomy Procedure

This study will enroll females who are ages 18 and older undergoing a laparoscopic or robotic, partial or full hysterectomy. Participants will be randomized to receive IV n-acetylcysteine or placebo during the first 60 minutes of their procedure. At various time points after the procedure patients will be asked to report their pain scores, and any pain medication taken.

Inclusion

• Undergoing elective laparoscopic or robotic, full, or partial hysterectomy procedure
• 18 years of age and older

Exclusion

• Less than 40kg in weight
• Unable to provide written, informed consent
• History of an adverse or anaphylactoid reaction to acetylcysteine
• Active asthma, wheezing, or using inhaled bronchodilators
• Non-English speaking
• Insulin dependent diabetes if D5W is required
• Blood clotting disorders