NAC vs Placebo on Opioid Use for Hysterectomy | NCT06039566 | Trialant

NAC vs Placebo on Opioid Use for Hysterectomy | NCT06039566 | Trialant

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
IV Placebo	Placebo Comparator	Patients will receive: Placebo 0 mg/kg (placebo: 0.45% NaCl or D5W) through an IV that will run for 60 minutes at the start of the procedure.	Drug: IV Placebo
IV N-acetylcysteine	Active Comparator	Patients will receive: N-acetylcysteine (NAC) 150 mg/kg (Max dose 15,000 mg) through an IV that will run for 60 minutes at the start of the procedure.	Drug: IV N-acetylcysteine

Interventions

Name	Type	Description	Arm Group Labels	Other Names
IV N-acetylcysteine	Drug	N-acetylcysteine (NAC) 150 mg/kg (Max dose 15,000 mg) through an IV that will run for 60 minutes at the start of the procedure	IV N-acetylcysteine

Outcomes Module

Secondary Outcomes

Measure	Description	Time Frame
Pain Scores	Using a Visual Analog Scale from 0-100, patients will report pain scores from 0-72 hours post-medication. A lower pain score means a better outcome.	Study medication start to 72 hours post-study medication

Other Outcomes

Measure	Description	Time Frame
intraoperative opioid consumption	Total morphine milligram equivalents administered during the procedure	during the procedure (up to 12 hours)
postoperative anesthesia care unit (PACU) opioid consumption

Contacts/Locations Module

Intervention Browse Module