The study was closed on 3/8/2021 as per final progress report issued by the IRB on 3/12/2021. No subjects were enrolled in the study following approval. Status changed to "Withdrawn (No Participants Enrolled)" accordingly.

This study is investigating whether administration of acetaminophen the day before surgery improves post operative pain following minimally invasive hysterectomy. Patients will receive either acetaminophen or placebo to take twice per day the day prior to their scheduled surgery. The morning of surgery all participants will receive oral acetaminophen at least 30 minutes prior to surgery. The investigators will examine whether there is a difference in post operative pain between the two groups.

Inclusion Criteria:

• Undergoing minimally invasive hysterectomy for benign indications

Exclusion Criteria:

• acetaminophen allergy
• liver disease
• kidney disease
• consume >3 alcoholic beverages per day
• weigh <50 kilograms
• report daily opiate use
• contraindication to acetaminophen
• used acetaminophen within 24 hours of surgery
• undergoing a concomitant pelvic reconstructive procedure