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This is study aim to compare between high flow nasal canula (HFNC) and non invasive positive pressure ventilation (NIPPV) in reducing the rate of reintubation in mechanically ventilated patient with successful weaning
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| high flow nasal cannula group | Active Comparator | patients put on high flow nasal cannula after extubation |
|
| non invasive positive pressure ventilation group | Active Comparator | patients put on non invasive positive pressure ventilation group after extubation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| high flow nasal cannula | Device | device are used for weaning patients after mechanical ventilation extubation |
|
| Measure | Description | Time Frame |
|---|---|---|
| the need for re-intubation and weaning success which will be measured by arterial blood gas ( ABG ) | baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Duration of using of HFNC or NIPPV | up to 30 days | |
| Length of hospital stay measured by days | up to 30 days | |
| In - hospital mortality measured by number of died cases |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| mohamed osman shehata abdelkareem, resident doctor | Contact | +201123368743 | abkmod@gmail.com | |
| Maha Kamel Ghanem, professor | Contact | +201227694434 | mahaghanem@hotmail.com |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25866645 | Background | Nishimura M. High-flow nasal cannula oxygen therapy in adults. J Intensive Care. 2015 Mar 31;3(1):15. doi: 10.1186/s40560-015-0084-5. eCollection 2015. | |
| 8147550 | Background | Meyer TJ, Hill NS. Noninvasive positive pressure ventilation to treat respiratory failure. Ann Intern Med. 1994 May 1;120(9):760-70. doi: 10.7326/0003-4819-120-9-199405010-00008. |
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| ID | Term |
|---|---|
| D012131 | Respiratory Insufficiency |
| ID | Term |
|---|---|
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
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When the patient become weanable from mechanical ventilation, the subjects were extubated immediately and randomly divided into two groups, with one group receiving HFNC (called HFNC group), the other group receiving NIPPV (called NIPPV group)
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| non invasive positive pressure ventilation | Device | device are used for weaning patients after mechanical ventilation extubation |
|
| up to 30 days |
| Adverse events | Adverse events (occurrence of nosocomial pneumonia based on clinical and laboratory and radiological finding, need for MV measured by re-intubation rate) | up to 30 days |
| Incidence of any possible complications associated with the use of HFNC and NIPPV | up to 30 days |
| 28089816 | Background | Ni YN, Luo J, Yu H, Liu D, Ni Z, Cheng J, Liang BM, Liang ZA. Can High-flow Nasal Cannula Reduce the Rate of Endotracheal Intubation in Adult Patients With Acute Respiratory Failure Compared With Conventional Oxygen Therapy and Noninvasive Positive Pressure Ventilation?: A Systematic Review and Meta-analysis. Chest. 2017 Apr;151(4):764-775. doi: 10.1016/j.chest.2017.01.004. Epub 2017 Jan 13. |
| 34955131 | Background | Fang G, Wan Q, Tian Y, Jia W, Luo X, Yang T, Shi Y, Gu X, Xu S. [Comparative study on pros and cons of sequential high-flow nasal cannula and non-invasive positive pressure ventilation immediately following early extubated patients with severe respiratory failure due to acute exacerbations of chronic obstructive pulmonary disease]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2021 Oct;33(10):1215-1220. doi: 10.3760/cma.j.cn121430-20210623-00939. Chinese. |
| 12172066 | Background | Gomez-Merino E, Sancho J, Marin J, Servera E, Blasco ML, Belda FJ, Castro C, Bach JR. Mechanical insufflation-exsufflation: pressure, volume, and flow relationships and the adequacy of the manufacturer's guidelines. Am J Phys Med Rehabil. 2002 Aug;81(8):579-83. doi: 10.1097/00002060-200208000-00004. |