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A Prospective, Single-center, Single-blind, Randomized split-face, controlled trial will be conducted. The goal of this clinical trial is to evaluate the efficacy and satisfaction of the Skinceuticals skin care product (CE) for skin repair following fraxel laser treatment and explore the medical value of fraxel laser therapy combined with Skinceuticals skin care product
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CE FERULIC | Experimental | fraxel laser therapy combined with Skinceuticals skin care product(CE FERULIC) and routine sun protection |
|
| 0.9% normal saline | Placebo Comparator | fraxel laser therapy combined with 0.9% normal saline and routine sun protection |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Skinceuticals skin care product(CE) | Other | Skinceuticals skin care product(CE FERULIC)+routine sun protection |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in erythema score | Scoring criteria: 0 (no erythema), 1 (mild erythema), 2 (moderate erythema), and 3 (severe erythema) | at day 7 post-procedure |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in erythema score | Scoring criteria: 0 (no erythema), 1 (mild erythema), 2 (moderate erythema), and 3 (severe erythema) | days 1, 3 post-procedure |
| Change from baseline in edema score |
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Inclusion Criteria:
Exclusion Criteria:
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| fraxel laser therapy | Other | Fraxel DUAL 1550/1927 Laser System |
|
| 0.9% normal saline | Other | 0.9% normal saline+routine sun protection |
|
Score 0 - no edema, score 1 - mild edema, score 2 - moderate edema, score 3 - severe edema
| days 1, 3,7 post-procedure |
| Change from baseline in Erythema Index (EI) | EI values were measured on both sides of their faces with a multifunctional skin tester MPA20 (Courage Khazaka, Germany) + Mexameter MX18 probe | days 1, 3,7 post-procedure |
| Change from baseline in melanin index(MI) | MI values were measured on both sides of their faces with a multifunctional skin tester MPA20 (Courage Khazaka, Germany) + Mexameter MX18 probe | days 1, 3,7 post-procedure |
| Change from baseline in stratum corneum water content | days 1, 3,7 post-procedure |
| Change from baseline in transepidermal water loss | days 1, 3,7 post-procedure |
| Change from baseline in sebum rate | days 1, 3,7 post-procedure |
| Subjects overall satisfaction | Satisfaction ratings were classified as: very satisfied, satisfied, dissatisfied, very dissatisfied | days 1, 3,7 post-procedure |
| Scab and desquamation | Record the start scab formation time, start scab removal time and complete scab removal time of subjects | days 1, 3,7 post-procedure |
| ID | Term |
|---|---|
| D000077330 | Saline Solution |
| ID | Term |
|---|---|
| D000077324 | Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |
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