Endocare Repair Efficacy Skincare Products in the Use of Post-laser Treatment

A Single-center, Prospective, Randomized, Double-blind, Self-controlled Clinical Study Evaluating the Efficacy and Safety of Endocare Repairing Skincare Product in Skin Recovery After Ablative Fractional Laser Treatment .

To Evaluate the Efficacy and Safety of Endocare Repair Efficacy Skincare Products in the Repair of Facial Skin Following Ablative Fractional Laser Treatment.

A single-center, prospective, randomized, double-blind, split-face (hemifacial) self-controlled clinical trial was conducted with 24 participants aged 21-37 years who underwent fractional CO2 laser treatment on both sides of the face. A skincare product containing SCA was applied to one side, and a placebo moisturizer was applied to the other side. Evaluations were conducted immediately after treatment and on days 1, 3, 5, 7, 14, and 28 post-treatment. The primary outcome was the evaluation of microcolumn density under dermoscopy. Secondary outcomes included transepidermal water loss (TEWL), melanin index (MI), erythema index (EI), investigator global assessment (IGA), patient global assessment(PGA), and visual analog scale (VAS) for pain. Safety was evaluated by monitoring adverse events.

Inclusion Criteria:

1. Individuals aged 30-65 years;
2. Candidates for ablative fractional laser treatment on the face;
3. Agree to undergo photographic documentation before and after the ablative fractional laser procedure and during follow-up visits;
4. Refrain from using other similar products (except facial cleansers) after ablative fractional laser treatment;
5. Written informed consent obtained.

Exclusion Criteria:

1. known hypersensitivity to product ingredients;
2. active skin infections;
3. history of keloid formation;
4. immunosuppressive therapy and pregnancy or lactation.