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Recently, few studies have attempted to test the regenerative effects of human insulin application by microneedling on atrophic scars versus other topical preparations. However, the scars were limited etiologically to acne scars. In addition, a lack of inclusion of a control group instead of comparing topical preparations with insulin was also a limitation to these studies. A control group consisting of microneedling alone would have served as a better comparison in order to determine whether the effects of microneedling are augmented by topical protein-rich preparations.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Microneedling with topical application of regular insulin | Active Comparator |
| |
| Microneedling only | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Microneedling with topical application of regular insulin | Other | Microneeling preformed onto the scar In one group insulin will be applied while saline will be used in the second group |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Scar | According the different scar assessment scores (e.g.POSAS score - The Patient and Observer Scar Assessment Scale score, range from 6 to 60, the higher the score the worse the scar, lowering in the score denotes improvement ) | 4 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Dalia I Halwag, PhD, MD | Contact | +00201224489473 | daliahalwag@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Alexandria University, Faculty of Medicine | Recruiting | Alexandria | Egypt |
Study protocol after finishing all the research and publishing the research
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| ID | Term |
|---|---|
| D002921 | Cicatrix |
| D007333 | Insulin Resistance |
| ID | Term |
|---|---|
| D005355 | Fibrosis |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D006946 | Hyperinsulinism |
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| ID | Term |
|---|---|
| D000097244 | Percutaneous Collagen Induction |
| ID | Term |
|---|---|
| D000529 | Complementary Therapies |
| D013812 | Therapeutics |
| D026741 | Physical Therapy Modalities |
| D011677 | Punctures |
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| Microneedling with topical application of saline | Other | Microneeling preformed onto the scar In one group insulin will be applied while saline will be used in the second group |
|
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D012046 |
| Rehabilitation |