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The purpose of this study is to assess the clinical and immunological effect of spirulina in treatment of stage II periodontitis.
In this study, the investigators tested the effect of spirulina gel as adjunctive of scaling and root planing in treatment of stage II, grade B periodontitis in term of probing pocket depth reduction, mean gain in clinical attachment level, and level of interleukin 6.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| oral hygiene instructions and SRP of all teeth plus placebo gel. | Placebo Comparator |
| |
| oral hygiene instructions and SRP of all teeth, followed by insertion of the spirulina gel. | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| spirulina gel | Drug | Patient were received spirulina gel in diseased sites. The process will be repeated at 7, 14, 21 days. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Clinical attachment level | Clinical attachment level was measured at baseline, 1 and 3 months after gel application. | 3 months |
| Probing pocket depth | Probing pocket depth was measured at baseline, 1 and 3 months after gel application. | 3 months |
| Interleukin 6. | Enzyme linked immune-assay for the quantitative measurement of interleukin 6 concentration in gingival cervicular fluid at baseline, 1 and 3 months after gel application. | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Plaque Index | Plaque index was measured at baseline and at 1, and 3-months post treatment. | 3 months |
| Gingival index | Gingival index was measured at baseline and at 1, and 3-months post treatment. |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kafrelsheikh University | Tanta | Egypt |
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| ID | Term |
|---|---|
| D010518 | Periodontitis |
| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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| SRP of all teeth | Procedure | Patients received oral hygiene instructions and SRP of all teeth. |
|
| 3 months |