When performing coronary angiography in a stable situation, the identification of an intermediate coronary lesion (between 50 and 70%) is common, and requires additional functional evaluation. The gold standard for this evaluation is Fractional Flow Reserve (FFR). FFR is a flow ratio transformed into a pressure ratio by simplification, neglecting some parameters, especially microcirculatory resistance.

The aim of this study is to investigate hemodynamic and structural assessment induced in specific conditions, and their repercussion on functional assessment by FFR to implement the diagnostic approach and personalize it for each patient.

Inclusion Criteria:

• Intermediate coronary lesion (between 50 and 70%)

Exclusion Criteria:

• Hemodynamic instability
• Adenosine hypersensitivity
• Asthma
• Severe chronic obstructive pulmonary disease
• Long QTc
• Wolff parkinson white
• High degree atriovenricular block
• Left-right shunt
• Carotid artery stenosis with hemodynamic insufficiency
• Pregnancy

• Diabetes mellitus
• High blood pressure
• Aortic stenosis
• Hypertrophic cardiopathy
• Dilated cardiopathy
• Stress cardiopathy
• Elderly people > 75 years old
• Acute coronary syndrome
• Preserved heart failure
• Cardiac amyloidosis

All collected data that underlie results in a publication

Data will be available beginning three years and ending fifteen years following the final study report completion

Data access requests will be reviewed by the internal committee of Brest UH. Requestors will be required to sign and complete a data access agreement.