Multimodal Epicardial and Endocardial COronary PHYsiological Evaluation in Pathological Situations (PHYCO)

Multimodal Epicardial and Endocardial COronary PHYsiological Evaluation in Pathological Situations

When performing coronary angiography in a stable situation, the identification of an intermediate coronary lesion (between 50 and 70%) is common, and requires additional functional evaluation. The gold standard for this evaluation is Fractional Flow Reserve (FFR). FFR is a flow ratio transformed into a pressure ratio by simplification, neglecting some parameters, especially microcirculatory resistance.

The aim of this study is to investigate hemodynamic and structural assessment induced in specific conditions, and their repercussion on functional assessment by FFR to implement the diagnostic approach and personalize it for each patient.

Inclusion Criteria:

• Intermediate coronary lesion (between 50 and 70%)

Exclusion Criteria:

• Hemodynamic instability
• Adenosine hypersensitivity
• Asthma
• Severe chronic obstructive pulmonary disease
• Long QTc
• Wolff parkinson white
• High degree atriovenricular block
• Left-right shunt
• Carotid artery stenosis with hemodynamic insufficiency
• Pregnancy