The goal of this observational study is to draw the characteristic maps of imaging omics, genomics, transcriptome, proteomics, pathological omics, metabolomics, etc. of the dynamic evolution of endometrial carcinogenesis in 100 patients with normal endometrium, 100 patients with atypical endometrial hyperplasia, and 100 patients with endometrial cancer; and then to explore the underlying molecular mechanism, and establish the database system for the dynamic evolution of endometrial carcinogenesis.

Inclusion Criteria:

• Pathological diagnosis: normal endometrium, atypical hyperplasia endometrium, or endometrial cancer;
• Obtain pathological results after undergoing hysteroscopic surgery or hysterectomy;
• The patient voluntarily participated in this research project with good compliance and was able to complete the enrollment according to the experimental requirements;
• Sign the informed consent form and consent to the collection and use of their data, and consent to genomics, transcriptome and other tests.

Exclusion Criteria:

• Patients with malignant tumors in other parts of the body;
• Suffering from uncontrollable neurological diseases, psychiatric diseases, or psychiatric disorders;
• Poor compliance and inability to cooperate and describe treatment responders.

Patients with normal endometrium (requiring diagnostic or therapeutic hysteroscopy or hysterectomy for other reasons), patients with precancerous lesions of endometrium, and patients with endometrial cancer who underwent surgery in the gynecology and obstetrics department of Renji Hospital affiliated to Shanghai Jiaotong University School of Medicine, whose illness was diagnosed as normal endometrium, atypical hyperplasia endometrium, or endometrial cancer by pathology.