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This study aims to analyze the multi-omics results between epithelial ovarian cancer (EOC) patient with different FIGO stages and pathological subtypes. The multi-omics profiles include whole exome sequencing, analysis of transcriptomics and metabolomics. A comprehensive multi-omics will reveal the invasiveness and tumorigenesis of EOC.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| A multi-omics analysis | Combination Product | A multi-omics analysis including whole exome sequencing, transcriptomics and metabolomics. |
| Measure | Description | Time Frame |
|---|---|---|
| Frequencies of somatic driving mutations | The differences of frequencies of somatic driving mutations will be compared between patients of different FIGO stages and different pathological subtypes. | Two years |
| Measure | Description | Time Frame |
|---|---|---|
| Frequencies of alteration of RNA expression | The alteration of RNA expression, including mRNA, miRNA, and lncRNA, will be compared between patients of different FIGO stages and different pathological subtypes. | Two years |
| Frequencies of alteration of protein expression and signal pathway |
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Inclusion Criteria:
Exclusion Criteria:
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Patients confirmed primary epithelial ovarian cancer will be included for analysis.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Lei Li, M.D. | Contact | 13911988831 | 86 | lileigh@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Lei Li, M.D. | Peking Union Medical College Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Lei Li | Recruiting | Beijing | Beijing Municipality | 100730 | China |
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| ID | Term |
|---|---|
| D000077216 | Carcinoma, Ovarian Epithelial |
| D063646 | Carcinogenesis |
| ID | Term |
|---|---|
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
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An 8 ml peripheral venous blood, and 50 μL cancer tissue and tissue adjacent to cancer will be collected from eligible patients.
The alteration of patterns of protein expression and signal pathway will be compared between patients of different FIGO stages and different pathological subtypes. |
| Two years |
| Progression-free survival | Progression-free survival between patients with differential expressed multi-omics will be compared. | Five years |
| D010051 |
| Ovarian Neoplasms |
| D004701 | Endocrine Gland Neoplasms |
| D009371 | Neoplasms by Site |
| D010049 | Ovarian Diseases |
| D000291 | Adnexal Diseases |
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D005833 | Genital Neoplasms, Female |
| D014565 | Urogenital Neoplasms |
| D000091662 | Genital Diseases |
| D004700 | Endocrine System Diseases |
| D006058 | Gonadal Disorders |
| D009385 | Neoplastic Processes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |