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This study aims to investigate the safety of serum product containing low dose of alpha hydroxy acid (AHA) i.e. 1% Glycolic acid and Lactic acid and Polyglutamate acid derivatives (PGA) for post-inflammatory hyperpigmentation skin in Malaysia. The study duration is 8 weeks and the skin assessment will be carried out at baseline, week 4 and week 8.The main questions this study aims to answer are:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Serum with low concentration AHA (1% Glycolic acid and Lactic acid) and PGA | Other | This serum containing low concentration AHA (1% Glycolic acid and Lactic acid) and PGA. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Serum with low concentration AHA (1% Glycolic acid and Lactic acid) and PGA | Other | Participants will used the serum twice daily for 8 weeks |
|
| Measure | Description | Time Frame |
|---|---|---|
| Adverse effect after using the serum. | Based on adverse effect occurrence on participants that occur during study period (8 weeks) | Week 8 |
| Measure | Description | Time Frame |
|---|---|---|
| Change in skin moisture level | Skin moisture will be measure using JANUS III skin analyzer and the changes in skin moisture from baseline and at week 4 and week 8 will be compared. | Baseline, Week 4 and Week 8 |
| Change in skin spot level |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ungku Shahrin Medical Aesthetic Research & Innovation (USMARI) Centre | Petaling Jaya | Selangor | 47810 | Malaysia |
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| ID | Term |
|---|---|
| D017495 | Hyperpigmentation |
| ID | Term |
|---|---|
| D010859 | Pigmentation Disorders |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
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| ID | Term |
|---|---|
| C031149 | glycolic acid |
| D019344 | Lactic Acid |
| D011454 | Prostaglandins A |
| ID | Term |
|---|---|
| D007773 | Lactates |
| D006880 | Hydroxy Acids |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
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Skin spot will be measure using JANUS III skin analyzer and the changes in skin spot from baseline and at week 4 and week 8 will be compared.
| Baseline, Week 4 and Week 8 |
| Change in skin pores level | Skin pores will be measure using JANUS III skin analyzer and the changes in skin pores from baseline and at week 4 and week 8 will be compared. | Baseline, Week 4 and Week 8 |
| Change in skin tone level | Skin tone will be measure using JANUS III skin analyzer and the changes in skin tone from baseline and at week 4 and week 8 will be compared. | Baseline, Week 4 and Week 8 |
| Participant satisfaction after using the serum for 8 week. | Participation satisfaction will be evaluated using the Physician Global Assessment (PGA) survey. The subjective score of changes in skin conditions including skin wrinkles, dryness, smoothness, moisturizing and brightening effect will be graded as follows: very satisfied, satisfied, neutral, dissatisfied, very dissatisfied. | Week 8 |
| D011453 |
| Prostaglandins |
| D015777 | Eicosanoids |
| D005231 | Fatty Acids, Unsaturated |
| D005227 | Fatty Acids |
| D008055 | Lipids |
| D012898 | Autacoids |
| D018836 | Inflammation Mediators |
| D001685 | Biological Factors |