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| Name | Class |
|---|---|
| Benha University | OTHER |
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Nausea and vomiting are some of the most common complaints of patients after any anesthesia, which is often associated with postop-erative pain. The double-blind clinical trial study aimed to compare the prophylactic effect of dexamethasone and dexmedetomidine and their combination in reducing postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control group | Placebo Comparator | received 20 ml normal saline |
|
| dexamethasone group | Active Comparator | received 8mg dexamethasone |
|
| dexmedetomidine group | Active Comparator | received dexmedetomidine 1mic/kg |
|
| combined group | Active Comparator | received combination of both 8mg dexamethasone+ dexmedetomidine 1mic/kg |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| normal Saline | Drug | Intraperitoneal route |
| |
| Dexamethasone |
| Measure | Description | Time Frame |
|---|---|---|
| The number of patients suffered from postoperative nausea and vomiting will be recorded in each group. | 24 hours postoperative |
| Measure | Description | Time Frame |
|---|---|---|
| antiemetic consumption | frequency of antiemetic consumption will be determined | 24 hours postoperatively |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Haney Baumey | Banhā | 13518 | Egypt | |||
| Neveen Kohaf |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40041104 | Derived | Bauiomy H, Kohaf NA, Saad M, Rashed ZF, Abosakaya AM. Study the Effect of Intraperitoneal Dexamethasone, Dexmedetomidine, and Their Combination on PONV After Laparoscopic Cholecystectomy: A Randomized Triple-Blind Trial. Anesthesiol Res Pract. 2025 Feb 24;2025:4976637. doi: 10.1155/anrp/4976637. eCollection 2025. |
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data could be shared upon reasonable request from principal investigator
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| Drug |
Intraperitoneal route |
|
| Dexmedetomidine | Drug | Intraperitoneal route |
|
| Combination of dexamethasone + dexmedetomidine | Drug | Intraperitoneal route |
|
| Tanta |
| 11865 |
| Egypt |
| ID | Term |
|---|---|
| D020250 | Postoperative Nausea and Vomiting |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009325 | Nausea |
| D012817 | Signs and Symptoms, Digestive |
| D012816 | Signs and Symptoms |
| D014839 | Vomiting |
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| ID | Term |
|---|---|
| D000077330 | Saline Solution |
| D003907 | Dexamethasone |
| D020927 | Dexmedetomidine |
| ID | Term |
|---|---|
| D000077324 | Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |
| D011246 | Pregnadienetriols |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D013259 | Steroids, Fluorinated |
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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