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Postoperative nausea and vomiting (PONV) are the most common and distressing side effects following Laparoscopic cholecystectomy
In the operating room, standard monitors included electrocardiogram, noninvasive arterial blood pressure, arterial oxygen saturation, and end-tidal carbon dioxide were connected. All patients received standardized anesthetic technique. At the end of surgery, gastric contents were suctioned via an orogastric tube before extubation. Atropine and neostigmine (1/2.5 mg) was given slowly I.V. to antagonize the residual neuromuscular block. Then, the trachea was extubated. Then, patients were transferred to the post-anesthesia care unit in a stable condition. Patients were allowed to drink liquids as soon as requested.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Dexamethasone Group | Active Comparator | I.V. Dexamethasone 5 mg just before induction plus intra-operative 10 ml/kg Ringer's lactate solution. |
|
| Dexamethasone and super-hydration Group | Active Comparator | I.V. Dexamethasone 5 mg just before induction of anesthesia plus intraoperative 30 ml/kg Ringer's lactate solution |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dexamethasone | Drug | 5 mg I.V. Dexamethasone just before induction |
|
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative Nausea and Vomiting (PONV) | A nurse, who was unaware about the groups to which the patient belonged, evaluated patients at 0, 6, and 24 h after surgery for any symptoms of nausea, retching, or vomiting. PONV is classified as early, if occurring up to 6h after surgery, or late, if occurring between 6 h up to 24 postoperatively. A Verbal Descriptive Scale (VDS), was used to assess the severity of PONV: no PONV (grade 0), mild PONV (grade 1), moderate PONV (grade 2) and severe PONV (grade 3) | Within the first 24 hours postoperatively |
| Measure | Description | Time Frame |
|---|---|---|
| Total number of patients who had nausea, vomiting or retching | Total number of patients who had nausea, vomiting or retching (number) | Within the first 24 hours postoperatively |
| Antiemetic usage |
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Inclusion Criteria:
American Society of Anesthesiologists (ASA) physical status I or II aged Elective laparoscopic cholecystectomy
Exclusion Criteria:
Steroids use within the last 3 days before surgery Antiemetic use within the last 3 days before surgery Opioids use within the last 3 days before surgery. Patients with liver, cardiac or renal diseases Patients with Pregnancy Patients with Bmi ˃ 30kg/m2 Patients with Delayed wound healing Open surgery
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| Name | Affiliation | Role |
|---|---|---|
| sayed abd elshafy, MD | associate professor of anesthesia and critical care | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Medicine | Asyut | Asyut Governorate | Egypt |
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| ID | Term |
|---|---|
| D020250 | Postoperative Nausea and Vomiting |
| D009325 | Nausea |
| D014839 | Vomiting |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012817 | Signs and Symptoms, Digestive |
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| ID | Term |
|---|---|
| D003907 | Dexamethasone |
| D002123 | Calcium Dobesilate |
| D000077325 | Ringer's Lactate |
| ID | Term |
|---|---|
| D011246 | Pregnadienetriols |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
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| 10 ml/kg Ringer's lactate | Drug | Intra-operative 10 ml/kg Ringer's lactate solution . |
|
|
| 30 ml/kg Ringer's lactate | Drug | Intra-operative 30 ml/kg Ringer's lactate solution . |
|
|
Total amount of ondansetron consumption (mg)
| Within the first 24 hours postoperatively |
| Pain Score | A visual analogue scale (appropriate score) | Within the first 24 hours postoperatively |
| Total analgesic consumption | I.V Pethidine (mg) | Within the first 24 hours postoperatively |
| Incidence of wound infection | Number of patients | Within the first week postoperatively |
| Incidence of delayed wound healing | Number of patients | Within the first week postoperatively |
| D012816 | Signs and Symptoms |
| D000072473 |
| Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D013259 | Steroids, Fluorinated |
| D001557 | Benzenesulfonates |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
| D001190 | Arylsulfonates |
| D017739 | Arylsulfonic Acids |
| D013451 | Sulfonic Acids |
| D013456 | Sulfur Acids |
| D013457 | Sulfur Compounds |
| D000077324 | Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |