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In this study, we aim to investigate the expression of CKLF like MARVEL transmembrane domain containing 6 (CMTM6) in leukemia cells of patients with acute myeloid leukemia (AML). We will use peripheral blood samples and assess CMTM6 expression by flow cytometry and Western Blot.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with AML | Peripheral blood will be taken at the timepoint of primary diagnosis and analyzed for CMTM6 expression and T cell activation | ||
| Healthy controls | Peripheral blood will be taken analyzed for CMTM6 expression and T cell activation |
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| Measure | Description | Time Frame |
|---|---|---|
| CMTM6 expression (FC) | CMTM6 expression on blasts/monocytes will be measured by flow cytometry | At primary diagnosis |
| T cell activation (FC) | T cell activation and cytokine production will be measured by flow cytometry | At primary diagnosis |
| Measure | Description | Time Frame |
|---|---|---|
| CMTM6 expression (WB) | CMTM6 expression on blasts/monocytes will be measured by Western blot | At primary diagnosis |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with AML at primary diagnosis ≥ 18 years of age
or
healthy probands ≥ 18 years of age
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical Center- University of Freiburg | Freiburg im Breisgau | CA | 79106 | Germany |
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| ID | Term |
|---|---|
| D015470 | Leukemia, Myeloid, Acute |
| ID | Term |
|---|---|
| D007951 | Leukemia, Myeloid |
| D007938 | Leukemia |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
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| D006402 |
| Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |