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Observation of the effects of cytokine adsorbent hemadsorption therapy on hemodynamics and mortality in critically ill patients who developed vasoplegic shock due to hyperinflammation without microbiological findings in the intensive care unit.
Observation of the effects of cytokine adsorbent hemadsorption therapy on hemodynamics and mortality in critically ill patients who developed vasoplegic shock due to hyperinflammation without microbiological findings and met the inclusion criteria in the Intensive Care Unit between 01.08.2023 and 01.02.2024
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| patients with vasoplegic shock | Application of cytokine hemadsorption therapy in patients with vasoplegic shock without microbiological findings |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| cytokine hemadsorption therapy | Procedure | Observation of cytokine hemadsorption therapy in critically ill patients who have no microbiological findings and develop vasoplegic shock. |
| Measure | Description | Time Frame |
|---|---|---|
| The time to resolution of vasoplegic shock within days. | From enrollment to the end of treatment at 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| 7-day mortality | 7 days | |
| mortality until discharge from hospital | From enrollment to the end of treatment at 12 weeks | |
| Interleukin 1 beta level on day 1 |
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Inclusion Criteria:
Exclusion Criteria:
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Thirty patients who met the inclusion criteria were included in the study.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Prof. Dr. Cemil Taşcıoğlu City Hospital | Istanbul | Şişli | 34384 | Turkey (Türkiye) |
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| one day |
| Interleukin 10 level on day 1 | one day |
| Interleukin 6 level on day 1 | one day |
| TNF - α level on day 1 | one day |
| Interleukin 1 beta level on day 3 | 3 days |
| Interleukin 10 level on day 3 | 3 days |
| Interleukin 6 level on day 3 | 3 days |
| TNF - α level on day 3 | 3 days |
| mechanical ventilation need and duration | From enrollment to the end of treatment at 12 weeks |
| duration of treatment in the intensive care unit | From enrollment to the end of treatment at 12 weeks |
| dose of catecholamine | From enrollment to the end of treatment at 12 weeks |
| ID | Term |
|---|---|
| D000080424 | Cytokine Release Syndrome |
| ID | Term |
|---|---|
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012769 | Shock |
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