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Cardiopulmonary surgery is associated with inflammatory responses that can lead to systemic inflammatory responses (SIRS), organ dysfunction (MOD) and death especially in patients with endocarditis. Cytokine removal might therefore improve outcomes of patients undergoing cardiac surgery. CytoSorb is a device designed to remove cytokine (IL-6, IL-10, TNFalpha) from the blood to reduce immune reactions. This trial investigates the use of CytoSorb during cardiac surgery in patients with endocarditis at the University Hospital Basel.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CytoSorb haemoadsorption (HA) device | Device | CytoSorb® cartridges contain biocompatible sorbent polystyrene divinylbenzene beads coated with polyvinylpyrrolidone, capable of removing inflammatory molecules (eg Interleukin). The cartridge is inserted in a cardio-pulmonary bypass circuit to remove inflammatory molecules during cardiac surgery . |
| Measure | Description | Time Frame |
|---|---|---|
| In-Hospital mortality | In-Hospital mortality (number of deaths) of patients with endocarditis undergoing cardiac surgery and intra-operative CytoSorb haemoadsorption | during hospital stay for cardiac surgery from admission until discharge (approximately 15 days) |
| Measure | Description | Time Frame |
|---|---|---|
| time in intensive care unit (days) | time in intensive care unit (days) | during hospital stay for cardiac surgery from admission until discharge (approximately 15 days) |
| In-Hospital time (days) |
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Inclusion Criteria:
Exclusion Criteria:
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patients with endocarditis undergoing cardiac surgery with cardio-pulmonary bypass circuit at the University Hospital Basel
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| Name | Affiliation | Role |
|---|---|---|
| David Santer, Dr. med | Universitätsspital Basel, Herzchirurgie | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Klinik für Herzchirurgie, Universitätsspital Basel | Basel | 4031 | Switzerland |
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| ID | Term |
|---|---|
| D004696 | Endocarditis |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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In-Hospital time (days)
| hospital stay for cardiac surgery from admission until discharge (approximately 15 days) |