To Explore the Efficacy and Safety of Surgical Treatment for Constipation, as Well as the Changes of Postoperative Intestinal Motility, Flora, Nutritional Status and Other Indicators

To Explore the Efficacy and Safety of Surgical Treatment for Constipation, as Well as the Changes of Postoperative Intestinal Motility, Flora, Nutritional Status and Other Indicators

Chronic constipation is a heterogeneous disease with multiple symptoms, and its incidence is on the rise in many countries. It has become a common disease affecting the quality of life. When these patients fail to respond to standardized and systematic non-surgical treatment, and the relevant examination suggests that there are surgical indications, surgical treatment should be considered. TThe objective of this study was to explore the efficacy and safety of surgical treatment for constipation, as well as the changes in postoperative nutrition, intestinal motility, intestinal flora and quality of life.

Inclusion Criteria:

• Disease duration more than 6 years;
• Wexner constipation score >15;
• No response to medical treatment, biofeedback and fecal microbiota transplantation;
• according to the surgical indications;
• All patients were informed of this study and signed the informed consent.

Exclusion Criteria:

• Suffering from mental disorders or cognitive impairment;
• With malignant tumors; -
• With history of gastrointestinal surgery;
• Complicated with other organ dysfunction;
• With immune system diseases.