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The goal of this clinical study is to investigate the effect of a curcuma longa oral gel (curenext) on reducing radiation-induced oral mucositis severity in cancer patients and provide a context for understanding if there is a relationship between the curcumin clinical effect and production of EGFs and IL8.
Researchers will compare between curcumin group and standard treatment group.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Curcuma longa oral gel group | Active Comparator |
| |
| Standard treatment group | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Curcumin Gel | Drug | Curcuma longa oral gel for prevention radiation induced oral mucositis |
|
| Measure | Description | Time Frame |
|---|---|---|
| Onset of radiation induced mucositis | Onset (at which week) of radiation induced mucositis in relation to EGF and IL8 | Assessment every week starting from first visit until the onset of mucositis (up to 2 months) |
| Change in severity of radiation induced mucositis | Change in severity (degree of illness) of radiation induced mucositis in relation to EGF & IL-8 by World Health Organization (WHO) mucositis scale {0: no. 1: mild. 2 and 3 : moderate. 4: severe} | Assessment every week starting from first visit of radiation unit it completion (average of 2 months) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nuclear medicine and radiation therapy hospital | Baghdad | 10053 | Iraq |
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| ID | Term |
|---|---|
| D006258 | Head and Neck Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| ID | Term |
|---|---|
| D012015 | Reference Standards |
| ID | Term |
|---|---|
| D014894 | Weights and Measures |
| D008919 | Investigative Techniques |
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Two groups A) curcuma longa oral gel group B) standard treatment group
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| Standard Preparation | Drug | Standard preparation for prevention radiation induced oral mucositis |
|