Topical oral vitamin D gel twice daily (Equivalent to 8000 I.U/day vitamin D) for six weeks.

Topical oral Vitamin D gel is prepared with the aid of pharmaceutics department, faculty of pharmacy, Alexandria University. It is prepared by using Cholecalciferol 2ml ampoule (200.000 I.U.) within topical oral gel formulation.

Conventional therapy (symptomatic treatment) which included:

• Miconaz oral gel
• BBC oral spray
• Oracure gel
• Alkamisr sachets

Dose: Three times a day for six weeks

Topical oral vitamin D gel twice daily (Equivalent to 8000 I.U/day vitamin D) for six weeks in combination with the symptomatic treatment

Symptomatic treatment which included:

• Miconaz oral gel
• BBC oral spray
• Oracure gel
• Alkamisr sachets

Symptomatic treatment dose: Three times a day for six weeks

vitamin D is a fat soluble vitamin which has important calcemic roles in the body regarding bone homeostasis and calcium/phosphorus balance. Recently, the non-calcemic roles of vitamin D as anti-inflammatory, anti-oxidant and immuno-regulatory functions have been widely reported.So, we tried to use it for prevention of radiation induced oral mucositis

Oral mucositis will be evaluated by the World Health Organization (WHO) scale which record the extent and severity of oral mucositis at the third and sixth week after the first radiotherapy session.

Discomfort and pain severity were reported by each patient using Numeric Rating Scale (NRS) at the third and sixth week after the first radiotherapy session.