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| Name | Class |
|---|---|
| Mayo Clinic | OTHER |
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The goal of this randomized, cross-over, single-site trial followed by an exploratory third intervention is to understand how indoor lighting affects different measures of brain health in older adults living in independent living residences. This is a community based study occurring in a local senior living facility. The main question this study aims to answer is:
- How does the quality of ambient indoor lighting an older adult is exposed to affect measures of brain health, such as sleep quality, physical activity, cognitive function, and social engagement?
Participants will be exposed to three different indoor lighting conditions for 4 weeks each while performing the following tasks:
Results from these tasks will be compared within and between subjects to assess whether the different lighting conditions affect these different measures of brain health.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| L1 then L2 followed by L3 lighting condition | Active Comparator | Participants will first experience a static lighting condition (L1) then a dynamic lighting condition (L2). After, participants will experience another dynamic lighting condition (L3) with increased morning brightness compared to L2. |
|
| L2 then L1 followed by L3 lighting condition | Active Comparator | Participants will first experience a dynamic lighting condition (L2) then a static lighting condition (L1). After, participants will experience another dynamic lighting condition (L3) with increased morning brightness compared to L2. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Static Lighting Condition (L1) | Behavioral | This indoor lighting condition keeps a constant brightness and correlated color temperature. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Total Sleep Time | Total sleep time per night in minutes as measured daily by a wearable device. | Change in total sleep time per night over the course of each condition of the 16-week study. |
| Wake After Sleep Onset | Wake after sleep onset per night in minutes as measured daily by a wearable device. | Change in wake after sleep onset per night over the course of each condition of the 16-week study. |
| Sleep State Duration | Sleep state duration per night in minutes as measured daily by a wearable device. | Change in sleep state duration per night over the course of each condition of the 16-week study. |
| Measure | Description | Time Frame |
|---|---|---|
| Sleep Quality | Self-report measurement of perceived sleep quality made daily via the Groningen Sleep Quality Survey. | Change in self-reported sleep quality over the course of each condition of the 16-week study. |
| Steps Taken |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Robert Klein, PhD | Contact | 507-258-7592 | robert.klein@delos.com | |
| Eric Heins | Contact | 507-259-0611 | eric.heins@delos.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Waters on Mayowood | Recruiting | Rochester | Minnesota | 55901 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39394603 | Derived | Mazurek KA, Li L, Klein RJ, Rong S, Mullan AF, Jones DT, St Louis EK, Worrell GA, Chen CY. Investigating the effects of indoor lighting on measures of brain health in older adults: protocol for a cross-over randomized controlled trial. BMC Geriatr. 2024 Oct 11;24(1):816. doi: 10.1186/s12877-023-04594-7. |
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| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D012934 | Social Isolation |
| ID | Term |
|---|---|
| D001519 | Behavior |
| D012919 | Social Behavior |
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| ID | Term |
|---|---|
| D020084 | Long Interspersed Nucleotide Elements |
| C010200 | inulin trinicotinate monomethochloride |
| ID | Term |
|---|---|
| D018626 | Retroelements |
| D020071 | Interspersed Repetitive Sequences |
| D012091 | Repetitive Sequences, Nucleic Acid |
| D001483 | Base Sequence |
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| Dynamic Lighting Condition (L2) | Behavioral | This indoor lighting condition has increased brightness and more blue correlated color temperature in the morning hours followed by decreased brightness and less blue correlated color temperature in the afternoon and evening hours. |
|
| Dynamic Lighting Condition (L3) | Behavioral | This exploratory indoor lighting condition matches the same pattern as L2 except the brightness in the morning hours is increased. |
|
Physical activity in steps per day as measured daily by a wearable device.
| Change in physical activity in steps per day over the course of each condition of the 16-week study. |
| Physical Activity | Physical activity in minutes per day as measured daily by a wearable device. | Change in physical activity in minutes per day over the course of each condition of the 16-week study. |
| Working Memory | Task performance on a working memory assessment taken twice weekly. | Change in working memory performance over the course of each condition of the 16-week study. |
| Task Switching | Task performance on a task switching assessment taken twice weekly. | Change in task switching performance over the course of each condition of the 16-week study. |
| Response Inhibition | Task performance on a response inhibition assessment taken twice weekly. | Change in response inhibition performance over the course of each condition of the 16-week study. |
| Sustained-Attention Reaction Time | Task performance on a sustained-attention reaction time assessment taken twice weekly. | Change in sustain-attention reaction time performance over the course of each condition of the 16-week study. |
| Self-Reported Loneliness | Self-report measurement of loneliness assessed weekly via the UCLA Loneliness Scale. | Change in self-reported loneliness over the course of each condition of the 16-week study. |
| Self-Reported Depression | Self-report measurement of depression assessed weekly via the Positive and Negative Affect Scale. | Change in self-reported depression over the course of each condition of the 16-week study. |
| Self-Reported Mood | Self-report measurement of mood assessed weekly via the Depression, Anxiety, and Stress Scale. | Change in self-reported mood over the course of each condition of the 16-week study. |
| D015394 | Molecular Structure |
| D001669 | Biochemical Phenomena |
| D055598 | Chemical Phenomena |
| D040342 | Genetic Structures |
| D055614 | Genetic Phenomena |
| D040481 | Genome Components |
| D016678 | Genome |