Investigating the Impact of Duration and Amount of Light on the Circadian System Response - Aim 3

Methodology Issues in a Tailored Light Treatment for Persons With Dementia - Aim 3

Investigate the long-term impact of amount and duration of Tailored Lighting Intervention (TLI) obtained from Aims 1 and 2 on sleep, cognition, circadian marker, mood, and behavior in AD/ADRD patients. For this single-arm, randomized, placebo-controlled study, the researchers plan to recruit 100 participants who will experience either the active TLI or the placebo for 6 months.

Inclusion Criteria:

• Diagnosis of Alzheimer's disease or related dementia with a Montreal Cognitive Assessment score <25
• Sleep disturbance with a Pittsburgh Sleep Quality Index score ≥5

Exclusion Criteria:

• Extensive brain vascular disease, traumatic brain injury, multiple sclerosis, Parkinson's Disease
• Obstructing cataracts
• Severe macular degeneration
• Use of sleep medication
• Use of oral melatonin
• untreated moderate to severe sleep apnea
• Severe restless leg syndrome - Blindness