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The goal of this clinical trial is to examine the effect of short-term L-Citrulline on central and peripheral blood pressure in healthy older adults. The main questions it aims to answer are:
Participants will be asked to consume L-citrulline and a placebo for six days and participate in the evaluation of their blood pressure, arterial stiffness, and muscle oxygenation before and after each intervention.
Researchers will compare L-citrulline and placebo groups to examine whether L-citrulline supplementation affects the above health parameters.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| L-Citrulline | Experimental | Participants will receive 6 g (3 g every 12 h) of L-citrulline (Now, L-citrulline Pure Powder) for six-days. |
|
| Placebo | Placebo Comparator | Participants will receive 6 g (3 g every 12 h) of maltodextrin (Now, Maltodextrin) for six-days. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| L-Citrulline | Dietary Supplement | 6 g (3 g every 12 h) of L-citrulline for six days |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Change in aortic and brachial systolic blood pressure (rest) | Change from baseline aortic and brachial systolic blood pressure at 7 days. | |
| Change in aortic and brachial systolic blood pressure | Change from baseline aortic and brachial systolic blood pressure at the second minute of exercise. | |
| Change in carotid-femoral pulse wave velocity (cfPWV) (rest) | Change from baseline aortic and brachial systolic blood pressure at 7 days. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in pulse pressure (rest) | Change from baseline pulse pressure at 7 days. | |
| Change in heart rate (rest) | Change from baseline heart rate at 7 days. | |
| Change in augmented pressure (rest) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Marios Vryonides, Dr. | European University Cyprus | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| European University Cyprus | Nicosia | 1516 | Cyprus |
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| ID | Term |
|---|---|
| D002956 | Citrulline |
| ID | Term |
|---|---|
| D000599 | Amino Acids, Diamino |
| D000596 | Amino Acids |
| D000602 | Amino Acids, Peptides, and Proteins |
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| Placebo |
| Dietary Supplement |
6 g (3 g every 12 h) of maltodextrin for six days |
|
| Change from baseline augmented pressure at 7 days. |
| Change in augmentation index (rest) | Change from baseline augmentation index at 7 days. |
| Change in forward and backward wave pressure (rest) | Change from baseline forward and backward wave pressure at 7 days. |
| Change in muscle oxyhemoglobin (rest) | Change from baseline oxyhemoglobin at 7 days. |
| Change in pulse pressure (exercise) | Change from baseline pulse pressure at the second minute of exercise. |
| Change in heart rate (exercise) | Change from baseline heart rate at the second minute of exercise. |
| Change in augmented pressure (exercise) | Change from baseline augmented pressure at the second minute of exercise. |
| Change in augmentation index (exercise) | The ideal augmentation index is between 20 and 80. Values above 80 are considered high, and above 121 indicate high arterial stiffness. | Change from baseline augmentation index at the second minute of exercise. |
| Change in forward and backward wave pressure (exercise) | Change from baseline forward and backward wave pressure at the second minute of exercise. |
| Change in muscle deoxyhemoglobin (exercise) | Change from baseline muscle deoxyhemoglobin at the second minute of exercise. |
| Change in muscle deoxyhemoglobin (rest) | Change from baseline muscle deoxyhemoglobin at 7 days. |
| Change in muscle oxyhemoglobin (exercise) | Change from baseline muscle oxyhemoglobin at the second minute of exercise. |
| Change in muscle oxyhemoglobin (rest) | Change from baseline muscle oxyhemoglobin at 7 days. |