Effect of L-Citrulline on Vascular Function

Impact of Reduced Arterial Stiffness on Peripheral Vascular Function and Mobility

The objective of this project is to determine the importance of peripheral vascular function on gait performance in older adults.

This project employed a placebo controlled, double-blind, crossover trial. Participants were randomized to oral L-citrulline (6 g/day) or placebo (maltodextrin) for 14 days, and switched to the other treatment for another 14 days after washout. Peripheral vascular function was assessed under conditions of rest, leg exercise, and cognitive engagement. Gait performance was assessed using clinical walking tests.

Inclusion Criteria:

• older adults
• women and men
• aged 60-79 yrs
• must be able to swallow capsules
• fully mobile without assistive walking devices

Exclusion Criteria:

• have physician diagnosed cardiovascular, pulmonary, or metabolic disease
• are current smokers
• currently taking medications affecting cardiovascular function
• have high blood pressure (>159/99 mmHG)
• have high fasting blood glucose (>110 mg/dL)
• are considered obese (body mass index ≥ 30 kg/m2)
• have orthopaedic limitations that limit walking ability
• have pacemaker or other metal objects in their body