Effect of Tadalafil, Sildenafil and Pentoxyfylline on Frozen Embryo Transfer Outcomes

"Effect of Tadalafil, Sildenafil and Pentoxyfylline on Endometrial Thickness and Frozen Embryo Transfer Outcomes

The aim of this study is to investigate the Effect of different vasodilators as Tadalafil, Sildenafil and pentoxyfylline in In vitro Fertilization. In addition, the thickness of endometrium and pregnancies rates of these women will also be examined. All adverse effects of all drugs will be estimated

A prospective randomized clinical study will be conducted in the IVF clinic of the gynecology department of Beni Suef University Hospital, Beni-Suef, Egypt. The study will These patients will be randomized into four groups.

The participants will take drugs starting from the end of menstruation cycle till endometrium reach optimal and then will start progesterone 800 mg daily.

Inclusion Criteria:

• women having thawed embryos

Exclusion Criteria:

• hypotension
• cardiovascular, hepatic, and renal diseases;
• uncontrolled diabetes mellitus;
• ovarian cysts;
• hyperprolactinemia;
• abnormal thyroid functions;
• uterine fibroids;
• patients taking nitrates;
• endometriosis and adenomyosis