Effect of Adding Sildenafil to Protocol of Endometrial Preparation in Outcome of Frozen-thawed Embryo Transfer Cycles

Effect of Adding Sildenafil to Protocol of Endometrial Preparation in Outcome of Frozen-thawed Embryo Transfer Cycles

The target of this study was an estimate the result of sildenafil on ultrasonographic endometrial thickness, endometrial pattern investigation estrogen level on the day of progesterone administration, Implantation rate and chemical pregnancy rate in frozen embryo transfer cycles .

Inclusion Criteria:

• women > 40 years old,
• history of endocrine disease
• Hysteroscopic surgery
• cardiovascular, renal and liver disease
• hypotension( blood pressure < 90/50)
• history of stroke or myocardial infarction
• use of alcohol or substance

Exclusion Criteria:

A total of 80 patients with antecedent of poor endometrial response and had frozen embryo included in this study all women must to be < 40 years old,

• no history of endocrine disease,
• no Hysteroscopic surgery, had a high quality embryos no cardiovascular,
• renal and liver disease and
• no hypotension (blood pressure < 90/50) or
• history of stroke or myocardial infarction and
• don't use of alcohol or substance Patients with these conditions enter this study and based on randomized tables are divided in two groups.