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| ID | Type | Description | Link |
|---|---|---|---|
| rad123 | Other Identifier | Shahid Sadoughi University of Medical Science | |
| rad123 | Other Identifier | Shahid Sadoughi University of Medical Science, Bouali Ave. Safaieh, Yazd,Iran. |
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| Name | Class |
|---|---|
| Razieh dehghani firouzabadi | UNKNOWN |
| Robab davar | UNKNOWN |
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The target of this study was an estimate the result of sildenafil on ultrasonographic endometrial thickness, endometrial pattern investigation estrogen level on the day of progesterone administration, Implantation rate and chemical pregnancy rate in frozen embryo transfer cycles .
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| sildenafil | Experimental | One of two group to prepare the endometrium give estradiol by step up method with menstruation. From first to fourth day of menstrual cycle, estradiol valerat tablet 2 mg daily From Fifth to eighth day of menstrual cycle, estradiol valerat tablet 4 mg daily From Ninth to twelfth day of menstrual , estradiol valerat tablet 6 mg daily The second group in addition to the above treatment protocol from First day of cycle until day of starting progesterone will be given sildenafil tablets(50 mg) daily. |
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| Sildenafil and estradiol valerat | Experimental | One of two group to prepare the endometrium give estradiol by step up method with menstruation. From first to fourth day of menstrual cycle, estradiol valerat tablet 2 mg daily From Fifth to eighth day of menstrual cycle, estradiol valerat tablet 4 mg daily From Ninth to twelfth day of menstrual , estradiol valerat tablet 6 mg daily The second group in addition to the above treatment protocol from First day of cycle until day of starting progesterone will be given sildenafil tablets(50 mg) daily. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sildenafil | Drug | sildenafil tablets(50 mg) daily |
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| Measure | Description | Time Frame |
|---|---|---|
| estimate the result of sildenafil on ultrasonographic endometrial thickness | Assays: Day 13 of menstrual cycle endometrial thickness estimated with Transvaginal ultrasonographic(arranged in a series every other day), evaluations were performed by a single investigator, If the endometrial thickness is more than 8mm progesterone injected 100 mg intramuscular and Estrogen, progesterone and lh measured in blood sample then after three days embryo transferred. | between 2009-2011 (up to 2 years) |
| Measure | Description | Time Frame |
|---|---|---|
| estimate the result of sildenafil on Implantation rate and chemical pregnancy rate in frozen embryo transfer cycles . | Implantation rate was higher in sildenafil Group but not significant chemical pregnancy rates were higher in sildenafil Group but not significant. | between 2009-2011 (up to 2 years) |
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Inclusion Criteria:
Exclusion Criteria:
A total of 80 patients with antecedent of poor endometrial response and had frozen embryo included in this study all women must to be < 40 years old,
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| Name | Affiliation | Role |
|---|---|---|
| farzaneh hojjat, MD | Department of Obstetrics and Gynecology, Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Science, Bouali Ave. Safaieh, Yazd,Iran. | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Farzaneh Hojjat | Yazd | 8916878466 | Iran |
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| ID | Term |
|---|---|
| D000068677 | Sildenafil Citrate |
| ID | Term |
|---|---|
| D013449 | Sulfonamides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D013450 | Sulfones |
| D013457 |
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| estradiol valerat | Drug |
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| Sulfur Compounds |
| D010879 | Piperazines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D011687 | Purines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |